Linked Life Data

947205

Source:http://linkedlifedata.com/resource/pubmed/id/947205

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1976-9-2
pubmed:abstractText
The influence of propranolol (0.3 and 1.0 mg/kg) and of D,L-4-(2-hydroxy-3-isopropylamino-propoxy)-indol-hydrochloride (pindolol, LB 46) (0.10, 0.25 and 0.50 mg/kg) on the responses of plasma potassium levels of anaesthetized dogs to slow i.v. infusions of adrenaline, noradrenaline and isoprenaline (5 mug/kg-min-1) was studied. Adrenaline and noradrenaline infusions regularly evoked a dual response (hyperkaliemia followed by hypokaliemia), whereas isoprenaline caused either similar effects or only a decrease of plasma potassium. Propranolol abolished the hypokaliemic phase of the responses to adrenaline, noradrenaline and isoprenaline; the lower dose used had no effect on the primary increase in plasma potassium, but the dose of 1.0 mg/kg modified this part of the response, which was reduced and became less steep. Pindolol antagonized in a dose dependent way the hypokaliemic phase of the responses to adrenaline, noradrenaline and isoprenaline, but did not interfere with the early rise in plasma potassium, thus being more specific than propranolol. It is concluded that the secondary decrease in plasma potassium is due to an activation of beta-receptors, whereas the initial increase is caused by alpha-receptor stimulation. Propranolol shows, in the 1.0 mg/kg dose, some alpha-blocking activity, thus contrasting with pindolol, which is devoid of this effect and therefore appears to be especially suitable for tentative characterization of adrenergic receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
238-41
pubmed:dateRevised
2009-10-27
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
A comparison between the influence of pindolol and propranolol on the response of plasma potassium to catecholamines.
pubmed:publicationType
Journal Article, Comparative Study