| pubmed-article:9472009 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9472009 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:9472009 | lifeskim:mentions | umls-concept:C2323499 | lld:lifeskim |
| pubmed-article:9472009 | lifeskim:mentions | umls-concept:C0530698 | lld:lifeskim |
| pubmed-article:9472009 | lifeskim:mentions | umls-concept:C0574895 | lld:lifeskim |
| pubmed-article:9472009 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:9472009 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:9472009 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:9472009 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:9472009 | pubmed:dateCreated | 1998-7-1 | lld:pubmed |
| pubmed-article:9472009 | pubmed:abstractText | The interleukin-5 (IL-5) receptor is a heterodimer that consists of an IL-5 specific alpha subunit and a common ssc chain that is shared with the receptors for granulocyte macrophage colony stimulating factor (GM-CSF) and interleukin-3 (IL-3). In contrast to IL-5, which acts mainly as an eosinophil lineage specific factor in vivo, IL-3 and GM-CSF stimulate the survival, proliferation and development of various hematopoietic cell lineages and also multipotent progenitor cells. IL-5 has little effect on the survival or proliferation of the multipotent stem cell line FDCP-Mix A4 but does promote some eosinophil development. To investigate whether the lineage specificity of IL-5 is due to the restricted expression of the IL-5 receptor alpha subunit we transfected the FDCP-Mix A4 cells with a retroviral vector containing this alpha subunit. The ectopic expression of the IL-5 receptor alpha subunit in the FDCP-Mix cells did not increase the observed eosinophilic development but did stimulate survival and proliferation of the transfected cells when IL-5 was added. IL-5 thus acts like IL-3 in these cells, promoting proliferation and survival. The results suggest that IL-5, whilst having a capacity to promote proliferation, does not influence eosinophilic lineage commitment in these multipotent cells. The results further argue that the observed lineage specificity of IL-5 is probably due to factors in addition to the restricted expression of the IL-5 receptor alpha subunit. | lld:pubmed |
| pubmed-article:9472009 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9472009 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472009 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9472009 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472009 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472009 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9472009 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9472009 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9472009 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:9472009 | pubmed:author | pubmed-author:DexterT MTM | lld:pubmed |
| pubmed-article:9472009 | pubmed:author | pubmed-author:TavernierJJ | lld:pubmed |
| pubmed-article:9472009 | pubmed:author | pubmed-author:SpooncerEE | lld:pubmed |
| pubmed-article:9472009 | pubmed:author | pubmed-author:PierceAA | lld:pubmed |
| pubmed-article:9472009 | pubmed:author | pubmed-author:HeyworthC MCM | lld:pubmed |
| pubmed-article:9472009 | pubmed:author | pubmed-author:WhettonA DAD | lld:pubmed |
| pubmed-article:9472009 | pubmed:author | pubmed-author:Owen-LynchP... | lld:pubmed |
| pubmed-article:9472009 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9472009 | pubmed:volume | 111 ( Pt 6) | lld:pubmed |
| pubmed-article:9472009 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9472009 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9472009 | pubmed:pagination | 815-23 | lld:pubmed |
| pubmed-article:9472009 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:meshHeading | pubmed-meshheading:9472009-... | lld:pubmed |
| pubmed-article:9472009 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9472009 | pubmed:articleTitle | Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line. | lld:pubmed |
| pubmed-article:9472009 | pubmed:affiliation | Leukemia Research Fund, Cellular Development Unit, UMIST, Manchester M60 1QD, UK. | lld:pubmed |
| pubmed-article:9472009 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9472009 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9472009 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9472009 | lld:pubmed |
