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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1998-2-19
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pubmed:abstractText |
Syndecan-1 is considered an important transmembrane proteoglycan in cell-microenvironment interactions, but its exact function in normal or in transformed B cells is still unknown. In this study, RNA was isolated from peripheral cells of chronic lymphocytic leukaemia (B-CLL) and 'normal', non-leukaemic patients, as controls. Reverse PCR showed no or very low syndecan-1 mRNA expression in controls, while in 11/13 B-CLL the circulating leukaemic cells expressed syndecan-1. Similar results were obtained for interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6). Furthermore, syndecan-1 protein was detected in the majority of circulating B-CLL cells by flow cytometry and immunocytochemistry using anti-syndecan-1 MAb. Control cells were practically negative. Further study is required to understand the biological significance of syndecan-1 on B-CLL cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/SDC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Syndecan-1,
http://linkedlifedata.com/resource/pubmed/chemical/Syndecans
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0959-8049
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2273-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9470818-Adult,
pubmed-meshheading:9470818-Aged,
pubmed-meshheading:9470818-Aged, 80 and over,
pubmed-meshheading:9470818-Female,
pubmed-meshheading:9470818-Flow Cytometry,
pubmed-meshheading:9470818-Gene Expression,
pubmed-meshheading:9470818-Humans,
pubmed-meshheading:9470818-Interleukin-1,
pubmed-meshheading:9470818-Interleukin-6,
pubmed-meshheading:9470818-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:9470818-Male,
pubmed-meshheading:9470818-Membrane Glycoproteins,
pubmed-meshheading:9470818-Middle Aged,
pubmed-meshheading:9470818-Neoplasm Proteins,
pubmed-meshheading:9470818-Polymerase Chain Reaction,
pubmed-meshheading:9470818-Proteoglycans,
pubmed-meshheading:9470818-RNA, Messenger,
pubmed-meshheading:9470818-RNA, Neoplasm,
pubmed-meshheading:9470818-Syndecan-1,
pubmed-meshheading:9470818-Syndecans
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pubmed:year |
1997
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pubmed:articleTitle |
Expression of syndecan-1 in human B cell chronic lymphocytic leukaemia.
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pubmed:affiliation |
First Institute of Pathology and Experimental Cancer Research, Budapest, Hungary.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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