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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1998-3-18
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pubmed:abstractText |
To elucidate the role of intestinal bacteria in the conversion of phylloquinone into menaquinone-4 (MK-4) we investigated the tissue distribution of vitamin K in germ-free rats. The rats were made vitamin K deficient by feeding a vitamin K-free diet for 13 days. In a subsequent period of 6 days, phylloquinone and menadione were supplied via the drinking water in concentrations of 10 and 50 micromol l(-1). Menadione supplementation led to high levels of tissue MK-4, particularly in extrahepatic tissues like pancreas, aorta, fat and brain. Liver and serum were low in MK-4. Phylloquinone supplementation resulted in higher phylloquinone levels in all tissues when compared with vitamin K-deficient values. The main target organs were liver, heart and fat. Remarkably, tissue MK-4 levels were also higher after the phylloquinone supplementation. The MK-4 tissue distribution pattern after phylloquinone intake was comparable with that found after menadione intake. Our results demonstrate that the conversion of phylloquinone into MK-4 in extrahepatic tissues may occur in the absence of an intestinal bacterial population and is tissue specific. A specific function for extrahepatic MK-4 or a reason for this biochemical conversion of phylloquinone into MK-4 remains unclear thus far.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
1379
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-75
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9468334-Animals,
pubmed-meshheading:9468334-Diet,
pubmed-meshheading:9468334-Germ-Free Life,
pubmed-meshheading:9468334-Intestines,
pubmed-meshheading:9468334-Male,
pubmed-meshheading:9468334-Rats,
pubmed-meshheading:9468334-Rats, Wistar,
pubmed-meshheading:9468334-Vitamin K,
pubmed-meshheading:9468334-Vitamin K 1,
pubmed-meshheading:9468334-Vitamin K 2,
pubmed-meshheading:9468334-Vitamin K Deficiency
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pubmed:year |
1998
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pubmed:articleTitle |
Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat.
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pubmed:affiliation |
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands.
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pubmed:publicationType |
Journal Article
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