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| pubmed-article:9468138 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:9468138 | lifeskim:mentions | umls-concept:C0439659 | lld:lifeskim |
| pubmed-article:9468138 | lifeskim:mentions | umls-concept:C0014499 | lld:lifeskim |
| pubmed-article:9468138 | pubmed:issue | 6667 | lld:pubmed |
| pubmed-article:9468138 | pubmed:dateCreated | 1998-3-2 | lld:pubmed |
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| pubmed-article:9468138 | pubmed:abstractText | There is considerable genetic diversity among viruses of different subtypes (designated A to J) in the major group of human immunodeficiency virus type 1 (HIV-1), the form of HIV that is dominant in the global epidemic. If available, HIV-1 sequences pre-dating the recognition of AIDS could be crucial in defining the time of origin and the subsequent evolution of these viruses in humans. The oldest known case of HIV-1 infection was reported to be that of a sailor from Manchester who died of an AIDS-like illness in 1959; however, the authenticity of this case has not been confirmed. Genetic analysis of sequences from clinical materials obtained from 1971 to 1976 from members of a Norwegian family infected earlier than 1971 showed that they carried viruses of the HIV-1 outlier group, a variant form that is mainly restricted to West Africa. Here we report the amplification and characterization of viral sequences from a 1959 African plasma sample that was previously found to be HIV-1 seropositive. Multiple phylogenetic analyses not only authenticate this case as the oldest known HIV-1 infection, but also place its viral sequence near the ancestral node of subtypes B and D in the major group, indicating that these HIV-1 subtypes, and perhaps all major-group viruses, may have evolved from a single introduction into the African population not long before 1959. | lld:pubmed |
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| pubmed-article:9468138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9468138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9468138 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9468138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9468138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9468138 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9468138 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:9468138 | pubmed:author | pubmed-author:NahmiasA JAJ | lld:pubmed |
| pubmed-article:9468138 | pubmed:author | pubmed-author:CuqPP | lld:pubmed |
| pubmed-article:9468138 | pubmed:author | pubmed-author:SharpP MPM | lld:pubmed |
| pubmed-article:9468138 | pubmed:author | pubmed-author:ZiaAA | lld:pubmed |
| pubmed-article:9468138 | pubmed:author | pubmed-author:KorberB TBT | lld:pubmed |
| pubmed-article:9468138 | pubmed:author | pubmed-author:HooperEE | lld:pubmed |
| pubmed-article:9468138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9468138 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:9468138 | pubmed:volume | 391 | lld:pubmed |
| pubmed-article:9468138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9468138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9468138 | pubmed:pagination | 594-7 | lld:pubmed |
| pubmed-article:9468138 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9468138 | pubmed:meshHeading | pubmed-meshheading:9468138-... | lld:pubmed |
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| pubmed-article:9468138 | pubmed:meshHeading | pubmed-meshheading:9468138-... | lld:pubmed |
| pubmed-article:9468138 | pubmed:meshHeading | pubmed-meshheading:9468138-... | lld:pubmed |
| pubmed-article:9468138 | pubmed:meshHeading | pubmed-meshheading:9468138-... | lld:pubmed |
| pubmed-article:9468138 | pubmed:meshHeading | pubmed-meshheading:9468138-... | lld:pubmed |
| pubmed-article:9468138 | pubmed:meshHeading | pubmed-meshheading:9468138-... | lld:pubmed |
| pubmed-article:9468138 | pubmed:meshHeading | pubmed-meshheading:9468138-... | lld:pubmed |
| pubmed-article:9468138 | pubmed:meshHeading | pubmed-meshheading:9468138-... | lld:pubmed |
| pubmed-article:9468138 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9468138 | pubmed:articleTitle | An African HIV-1 sequence from 1959 and implications for the origin of the epidemic. | lld:pubmed |
| pubmed-article:9468138 | pubmed:affiliation | Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA. | lld:pubmed |
| pubmed-article:9468138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9468138 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9468138 | pubmed:publicationType | Historical Article | lld:pubmed |
| pubmed-article:9468138 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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