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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6667
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pubmed:dateCreated |
1998-3-2
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030526,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030527,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030528,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030529,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030530,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030531,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030532,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030533,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030534,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030535,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030536,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030537,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030538,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030539,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030540,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030541,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030543,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030544,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030637,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030638,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030639,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030640,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030641,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030642,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030643,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030644,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030645,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030646,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030647,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF030648
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pubmed:abstractText |
There is considerable genetic diversity among viruses of different subtypes (designated A to J) in the major group of human immunodeficiency virus type 1 (HIV-1), the form of HIV that is dominant in the global epidemic. If available, HIV-1 sequences pre-dating the recognition of AIDS could be crucial in defining the time of origin and the subsequent evolution of these viruses in humans. The oldest known case of HIV-1 infection was reported to be that of a sailor from Manchester who died of an AIDS-like illness in 1959; however, the authenticity of this case has not been confirmed. Genetic analysis of sequences from clinical materials obtained from 1971 to 1976 from members of a Norwegian family infected earlier than 1971 showed that they carried viruses of the HIV-1 outlier group, a variant form that is mainly restricted to West Africa. Here we report the amplification and characterization of viral sequences from a 1959 African plasma sample that was previously found to be HIV-1 seropositive. Multiple phylogenetic analyses not only authenticate this case as the oldest known HIV-1 infection, but also place its viral sequence near the ancestral node of subtypes B and D in the major group, indicating that these HIV-1 subtypes, and perhaps all major-group viruses, may have evolved from a single introduction into the African population not long before 1959.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
391
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
594-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9468138-Democratic Republic of the Congo,
pubmed-meshheading:9468138-Disease Outbreaks,
pubmed-meshheading:9468138-Evolution, Molecular,
pubmed-meshheading:9468138-HIV Infections,
pubmed-meshheading:9468138-HIV-1,
pubmed-meshheading:9468138-History, 20th Century,
pubmed-meshheading:9468138-Humans,
pubmed-meshheading:9468138-Male,
pubmed-meshheading:9468138-Molecular Sequence Data,
pubmed-meshheading:9468138-Phylogeny,
pubmed-meshheading:9468138-Polymerase Chain Reaction,
pubmed-meshheading:9468138-RNA, Viral,
pubmed-meshheading:9468138-Sequence Alignment
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pubmed:year |
1998
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pubmed:articleTitle |
An African HIV-1 sequence from 1959 and implications for the origin of the epidemic.
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pubmed:affiliation |
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Historical Article,
Research Support, Non-U.S. Gov't
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