Linked Life Data

9467564

Source:http://linkedlifedata.com/resource/pubmed/id/9467564

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-2-27
pubmed:abstractText
The activity of the hypothalamic-GH-insulin-like growth factor (IGF) network declines with age. It has recently been shown that increased cardiovascular mortality occurs in adults with GH deficiency. As hypercholesterolemia is common in GH-deficient adults, and because there is experimental evidence that GH may play a role in regulating plasma cholesterol, we decided to investigate the activity of the GH-IGF axis in an elderly population by measuring serum IGF-I, IGF-II, and IGF-binding protein-3 (IGFBP-3) levels and to study their relationship with blood lipid levels. One hundred and thirty-two elderly subjects, 52 men and 80 women, were studied (age range, 60-91 yr). Men had significantly lower levels of IGFBP-3, high density lipoprotein cholesterol (HDL-C) and apoprotein A1 (ApoA1) compared to the women, whereas IGF-I and IGF-II were only slightly lower. Using linear regression analysis, we observed an inverse relationship of age with IGF-I (r = -0.35; P < 0.001), IGF-II (r = 0.40; P < 0.001), IGFBP-3 (r = 0.52; P < 0.001), body mass index, and lipid levels. Univariate regression analysis showed a strong and positive correlation of both IGF-I and IGFBP-3 with HDL-C and ApoA1. Partial correlation analysis, after adjustment for age and body mass index, showed that IGFBP-3 and IGF-II were still significantly and positively related to HDL-C and ApoA1. Furthermore, a strong association was documented among IGF-I, IGF-II, and IGFBP-3. These data demonstrate that even in an elderly population, further aging is accompanied by a progressive decline in circulating IGF-I, IGF-II, and IGFBP-3, suggesting a continuing diminution of the GH-IGF axis throughout aging. Moreover, the strong correlation between HDL-C and an index of GH secretion, such as IGFBP-3, suggests that GH might play an important role in lipid metabolism in healthy elderly subjects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
499-502
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9467564-Aged, pubmed-meshheading:9467564-Aged, 80 and over, pubmed-meshheading:9467564-Aging, pubmed-meshheading:9467564-Apolipoprotein A-I, pubmed-meshheading:9467564-Body Mass Index, pubmed-meshheading:9467564-Cholesterol, HDL, pubmed-meshheading:9467564-Female, pubmed-meshheading:9467564-Human Growth Hormone, pubmed-meshheading:9467564-Humans, pubmed-meshheading:9467564-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:9467564-Insulin-Like Growth Factor I, pubmed-meshheading:9467564-Insulin-Like Growth Factor II, pubmed-meshheading:9467564-Lipids, pubmed-meshheading:9467564-Male, pubmed-meshheading:9467564-Middle Aged, pubmed-meshheading:9467564-Regression Analysis, pubmed-meshheading:9467564-Sex Characteristics, pubmed-meshheading:9467564-Triglycerides
pubmed:year
1998
pubmed:articleTitle
The insulin-like growth factor axis and plasma lipid levels in the elderly.
pubmed:affiliation
Cattedra di Geriatria, Università di Parma, Italy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.