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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-3-6
|
| pubmed:abstractText |
Thirty-seven matched cerebrospinal fluid (CSF) and plasma samples from 34 human immunodeficiency virus type 1 (HIV-1)-infected patients with suspected meningitis were analyzed for levels of HIV-1 RNA and markers of inflammation. Patients with tuberculous (n = 9) or cryptococcal (n = 6) meningitis had the highest CSF virus loads, which in many cases exceeded the levels in plasma, compared with patients with meningococcal meningitis (n = 3), aseptic meningitis (n = 8), tuberculoma (n = 2), or AIDS dementia complex (n = 4) or with normal lumbar punctures (n = 3). CSF virus load correlated significantly with the number of infiltrating lymphocytes (r = .60, P < .001) but not with plasma virus load, the levels of beta2-microglobulin in the CSF, or the integrity of the blood-brain barrier. These data suggest significant intrathecal HIV-1 replication in patients with lymphocytic meningeal infections such as tuberculous and cryptococcal meningitis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
177
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
473-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9466541-AIDS Dementia Complex,
pubmed-meshheading:9466541-Blood-Brain Barrier,
pubmed-meshheading:9466541-CD4 Lymphocyte Count,
pubmed-meshheading:9466541-Cryptococcosis,
pubmed-meshheading:9466541-HIV Core Protein p24,
pubmed-meshheading:9466541-HIV Infections,
pubmed-meshheading:9466541-HIV-1,
pubmed-meshheading:9466541-Humans,
pubmed-meshheading:9466541-Leukocyte Count,
pubmed-meshheading:9466541-Lymphocytes,
pubmed-meshheading:9466541-Meningitis,
pubmed-meshheading:9466541-Meningitis, Aseptic,
pubmed-meshheading:9466541-Meningitis, Fungal,
pubmed-meshheading:9466541-Meningitis, Meningococcal,
pubmed-meshheading:9466541-RNA, Viral,
pubmed-meshheading:9466541-Tuberculosis, Meningeal,
pubmed-meshheading:9466541-Viral Load,
pubmed-meshheading:9466541-beta 2-Microglobulin
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
High human immunodeficiency virus type 1 RNA load in the cerebrospinal fluid from patients with lymphocytic meningitis.
|
| pubmed:affiliation |
National Institute for Virology, Department of Virology, University of the Witwatersrand, Johannesburg, South Africa. lmorris@adarc.org
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|