Linked Life Data

9466431

Source:http://linkedlifedata.com/resource/pubmed/id/9466431

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-3-26
pubmed:abstractText
During histogenesis of the neocortex, Cajal Retzius cells in the marginal zone express the glycoprotein reelin which is developmentally regulated and involved in the formation of the inside out mode of cortical layering. Cajal Retzius cells are also present in the developing hippocampus. There, inhibition of reelin by blocking with CR-50, an antibody which recognizes the N-terminus of this protein, leads to abnormal development of layer-specific connections. Here we report the developmental distribution pattern of reelin expressing neurons in the rat hippocampal formation using CR-50 immunocytochemistry. Labelled Cajal Retzius cells were located near the hippocampal fissure in neonate rats. Many of these cells were still present in the adult. From postnatal day 4 on, neurons in other layers were stained with the CR-50 antibody. In adult rats immunopositive neurons were found in all hippocampal subfields and in the entorhinal cortex. These observations indicate that in the rat hippocampal formation reelin is expressed in different neuronal types during development and in adulthood. Moreover, Cajal Retzius cells in the marginal zone near the hippocampal fissure are still found in adult animals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1079-86
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Developmental distribution of a reeler gene-related antigen in the rat hippocampal formation visualized by CR-50 immunocytochemistry.
pubmed:affiliation
Institute of Anatomy, University of Freiburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't