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pubmed-article:9465841pubmed:abstractTextSirolimus and cyclosporine (INN, ciclosporin) share the same cytochrome P4503A metabolic pathways, and both drugs are substrates for p-glycoprotein countertransport. These factors most likely affect the bioavailability of both drugs. This study served to examine whether the timing of the administration of cyclosporine and sirolimus might significantly affect the relative bioavailability of one or both of these drugs.lld:pubmed
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pubmed-article:9465841pubmed:articleTitleThe effects of relative timing of sirolimus and cyclosporine microemulsion formulation coadministration on the pharmacokinetics of each agent.lld:pubmed
pubmed-article:9465841pubmed:affiliationDepartment of Surgery, University of Texas Medical School at Houston 77030, USA.lld:pubmed
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