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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-2-27
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pubmed:abstractText |
Sirolimus and cyclosporine (INN, ciclosporin) share the same cytochrome P4503A metabolic pathways, and both drugs are substrates for p-glycoprotein countertransport. These factors most likely affect the bioavailability of both drugs. This study served to examine whether the timing of the administration of cyclosporine and sirolimus might significantly affect the relative bioavailability of one or both of these drugs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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|
pubmed:issn |
0009-9236
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-53
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9465841-Adult,
pubmed-meshheading:9465841-Cross-Over Studies,
pubmed-meshheading:9465841-Cyclosporine,
pubmed-meshheading:9465841-Drug Administration Schedule,
pubmed-meshheading:9465841-Emulsions,
pubmed-meshheading:9465841-Female,
pubmed-meshheading:9465841-Humans,
pubmed-meshheading:9465841-Immunosuppressive Agents,
pubmed-meshheading:9465841-Kidney Transplantation,
pubmed-meshheading:9465841-Male,
pubmed-meshheading:9465841-Middle Aged,
pubmed-meshheading:9465841-Polyenes,
pubmed-meshheading:9465841-Sirolimus
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pubmed:year |
1998
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|
pubmed:articleTitle |
The effects of relative timing of sirolimus and cyclosporine microemulsion formulation coadministration on the pharmacokinetics of each agent.
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pubmed:affiliation |
Department of Surgery, University of Texas Medical School at Houston 77030, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
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