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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1998-3-20
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pubmed:abstractText |
To assess the role of the mossy fibre-granule cell pathway in learning, the cerebellum of young DA/HAN strain rats was irradiated to make the cortex completely or partially agranular. The X-rays were delivered according to two different schedules, between 5-14 postnatal days (early group) and between 10-14 postnatal days (late group). Histological controls at 35 days showed a mean loss of granule cells of 96 +/- 1% in the early group and of 61 +/- 3% in the late group. The irradiated animals were subjected, from day 23 to day 35, to daily sensorimotor training on a rotorod. The scores and the strategy used (walking or hanging) by the rats were noted. The results demonstrate that a partial loss of granule cells due to a late X-irradiation schedule induced mild motor disabilities but no learning deficit, the only problem being difficulty in elaborating rapidly an efficient strategy to solve a novel problem. A sub-total loss of the granule cells, due to an early X-irradiation schedule, induced gross motor disabilities and the animals used hanging > 90% of the time. Due to the discrepancy between the learning abilities, which were preserved at least in part, and the gross motor impairments, the animals elaborated a novel strategy (jumping from the beam), allowing them to escape the experimental situation. This avoidance behaviour may be due to a decrease of anxiety, a lack of behavioural inhibition and/or attentional deficits that have been already observed in several other examples of cerebellar abnormalities.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0953-816X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2472-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9464941-Aging,
pubmed-meshheading:9464941-Animals,
pubmed-meshheading:9464941-Animals, Newborn,
pubmed-meshheading:9464941-Behavior, Animal,
pubmed-meshheading:9464941-Cerebellum,
pubmed-meshheading:9464941-Cytoplasmic Granules,
pubmed-meshheading:9464941-Learning,
pubmed-meshheading:9464941-Neural Pathways,
pubmed-meshheading:9464941-Postural Balance,
pubmed-meshheading:9464941-Rats,
pubmed-meshheading:9464941-Rats, Inbred Strains,
pubmed-meshheading:9464941-X-Rays
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pubmed:year |
1997
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pubmed:articleTitle |
Effect of cerebellar granule cell depletion on learning of the equilibrium behaviour: study in postnatally X-irradiated rats.
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pubmed:affiliation |
Laboratoire de Neurophysiologie Sensorielle, Faculté des Sciences, Université de Rouen, Mont-Saint-Aignan, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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