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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
10
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|
pubmed:dateCreated |
1998-2-19
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|
pubmed:abstractText |
The anti-estrogen drug tamoxifen (TMX) was found to act as a strong inhibitor of purified neuronal nitric oxide synthase (nNOS) (IC50 = 2 +/- 0.5 microM), whereas it was inactive toward inducible macrophage NOS (IC50 > 100 microM). TMX affected the activation of NOS by calmodulin, as it not only inhibited L-arginine oxidation to nitric oxide and L-citrulline but also NADPH oxidation and calmodulin-dependent cytochrome c reduction catalyzed by nNOS. These results suggest that TMX could exert some of its biological effects by interfering with constitutive NOS-dependent formation of nitric oxide and/or superoxide ion in various tissues.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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|
pubmed:month |
Nov
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|
pubmed:issn |
0006-2952
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
15
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|
pubmed:volume |
54
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1109-14
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9464453-Animals,
pubmed-meshheading:9464453-Calmodulin,
pubmed-meshheading:9464453-Enzyme Inhibitors,
pubmed-meshheading:9464453-Estrogen Antagonists,
pubmed-meshheading:9464453-Mice,
pubmed-meshheading:9464453-Mice, Inbred C3H,
pubmed-meshheading:9464453-Neurons,
pubmed-meshheading:9464453-Nitric Oxide Synthase,
pubmed-meshheading:9464453-Nitric Oxide Synthase Type I,
pubmed-meshheading:9464453-Rats,
pubmed-meshheading:9464453-Tamoxifen
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pubmed:year |
1997
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|
pubmed:articleTitle |
Strong inhibition of neuronal nitric oxide synthase by the calmodulin antagonist and anti-estrogen drug tamoxifen.
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|
pubmed:affiliation |
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Université R. Descartes, Paris, France.
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pubmed:publicationType |
Journal Article
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