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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-5-1
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pubmed:abstractText |
During the development of the egg-laying system in Caenorhabditis elegans hermaphrodites, central gonadal cells organize the alignment of the vulva with the sex myoblasts, the progenitors of the egg-laying muscles. A fibroblast growth factor [EGL-17(FGF)] and an FGF receptor [EGL-15(FGFR)] are involved in the gonadal signals that guide the migrations of the sex myoblasts. Here we show that EGL-17(FGF) can act as an instructive guidance cue to direct the sex myoblasts to their final destinations. We find that egl-17 reporter constructs are expressed in the primary vulval cell and that EGL-17(FGF) expression in this cell correlates with the precise positioning of the sex myoblasts. We postulate that EGL-17(FGF) helps to coordinate the development of a functional egg-laying system, linking vulval induction with proper sex myoblast migration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1083-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9463355-Animals,
pubmed-meshheading:9463355-Caenorhabditis elegans,
pubmed-meshheading:9463355-Caenorhabditis elegans Proteins,
pubmed-meshheading:9463355-Cell Movement,
pubmed-meshheading:9463355-Female,
pubmed-meshheading:9463355-Gene Expression Regulation, Developmental,
pubmed-meshheading:9463355-Genes, Helminth,
pubmed-meshheading:9463355-Genes, Reporter,
pubmed-meshheading:9463355-Genitalia, Female,
pubmed-meshheading:9463355-Green Fluorescent Proteins,
pubmed-meshheading:9463355-Growth Substances,
pubmed-meshheading:9463355-Helminth Proteins,
pubmed-meshheading:9463355-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:9463355-Luminescent Proteins,
pubmed-meshheading:9463355-Male,
pubmed-meshheading:9463355-Models, Biological,
pubmed-meshheading:9463355-Muscle Development,
pubmed-meshheading:9463355-Muscles,
pubmed-meshheading:9463355-Mutation,
pubmed-meshheading:9463355-Stem Cells,
pubmed-meshheading:9463355-Vulva
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pubmed:year |
1998
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pubmed:articleTitle |
EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans.
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pubmed:affiliation |
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8005, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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