|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1998-3-12
|
|
pubmed:abstractText |
In an effort to identify an immunological basis for natural resistance to HIV-1 infection, we have examined serum antibody responses to HLA class I antigens in female prostitutes of the Nairobi Sex Workers Study. Anti-HLA antibodies are known to block HIV infectivity in vitro and can be protective against SIV challenge in macaques immunized with purified class I HLA. Thus, it was postulated that broadly cross-reactive alloantibodies recognizing common HLA alleles in the client population might contribute to the prevention of heterosexual transmission of HIV. In fact, 12% of the women were found to have serum IgG antibodies against class I alloantigens. However, this alloantibody did not correlate with the HIV status of the women and was found in a similar proportion of HIV-positive and HIV-resistant women. The observed levels of alloantibody did not increase with HIV infection in susceptible individuals, suggesting that potential antigenic mimicry between HIV and host HLA class I antigens does not significantly increase levels of anti-class I antibodies. The lack of correlation between serum anti-allo-class I HLA antibodies and the risk of sexual transmission indicates that this humoral immune response is unlikely to be the natural mechanism behind the HIV-resistance phenotype of persistently HIV-seronegative women. This result, however, does not preclude the further investigation of alloimmunization as an artificial HIV immunization strategy.
|
|
pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/ANTIBODIES,
http://linkedlifedata.com/resource/pubmed/keyword/ANTIGENS,
http://linkedlifedata.com/resource/pubmed/keyword/Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Africa South Of The Sahara,
http://linkedlifedata.com/resource/pubmed/keyword/Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Cohort Analysis,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Eastern Africa,
http://linkedlifedata.com/resource/pubmed/keyword/English Speaking Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Hiv Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Hiv Serodiagnosis,
http://linkedlifedata.com/resource/pubmed/keyword/IMMUNITY,
http://linkedlifedata.com/resource/pubmed/keyword/Immunity, Natural,
http://linkedlifedata.com/resource/pubmed/keyword/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Kenya,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Prostitutes--women,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Sex Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Viral Diseases
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0889-2229
|
|
pubmed:author |
pubmed-author:AnzalaA OAO,
pubmed-author:BallT BTB,
pubmed-author:BarberB HBH,
pubmed-author:BwayoJ JJJ,
pubmed-author:ChouCC,
pubmed-author:LuscherM AMA,
pubmed-author:MacDonaldK SKS,
pubmed-author:Ndinya-AcholaJ OJO,
pubmed-author:NjagiEE,
pubmed-author:PlummerF AFA,
pubmed-author:WadeJ AJA
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
20
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
109-15
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:9462920-Cohort Studies,
pubmed-meshheading:9462920-Cross-Sectional Studies,
pubmed-meshheading:9462920-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9462920-Female,
pubmed-meshheading:9462920-HIV Infections,
pubmed-meshheading:9462920-HIV-1,
pubmed-meshheading:9462920-Histocompatibility Antigens Class I,
pubmed-meshheading:9462920-Humans,
pubmed-meshheading:9462920-Immunity, Innate,
pubmed-meshheading:9462920-Immunoglobulin G,
pubmed-meshheading:9462920-Isoantibodies,
pubmed-meshheading:9462920-Kenya,
pubmed-meshheading:9462920-Longitudinal Studies,
pubmed-meshheading:9462920-Prostitution
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Naturally occurring IgG anti-HLA alloantibody does not correlate with HIV type 1 resistance in Nairobi prostitutes.
|
|
pubmed:affiliation |
Department of Immunology, University of Toronto, The Toronto Hospital, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
