| pubmed-article:9462514 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9462514 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9462514 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:9462514 | lifeskim:mentions | umls-concept:C2926735 | lld:lifeskim |
| pubmed-article:9462514 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9462514 | pubmed:dateCreated | 1998-2-24 | lld:pubmed |
| pubmed-article:9462514 | pubmed:abstractText | It is known that T cells engage antigen-presenting cells (APCs) in a stable interaction that results in sustained TCR signaling. We show here that the duration of this process is critical in determining whether T cells will be activated or deleted. Whereas naive T cells require approximately 20 hr of sustained signaling to be committed to proliferation, effector T cells become committed after only 1 hr but die following activation if antigenic stimulation is prolonged. Costimulation by anti-CD28 facilitates T cell activation by decreasing the time of commitment and by protecting T cells from death. These findings explain in quantitative terms the essential requirement for professional APCs in T cell priming and show that the duration of antigenic stimulation is the major factor determining the fate of naive and effector T cells. | lld:pubmed |
| pubmed-article:9462514 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9462514 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9462514 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9462514 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9462514 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9462514 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9462514 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9462514 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9462514 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:9462514 | pubmed:author | pubmed-author:KarjalainenKK | lld:pubmed |
| pubmed-article:9462514 | pubmed:author | pubmed-author:LanzavecchiaA... | lld:pubmed |
| pubmed-article:9462514 | pubmed:author | pubmed-author:IezziGG | lld:pubmed |
| pubmed-article:9462514 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9462514 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9462514 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9462514 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9462514 | pubmed:pagination | 89-95 | lld:pubmed |
| pubmed-article:9462514 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:meshHeading | pubmed-meshheading:9462514-... | lld:pubmed |
| pubmed-article:9462514 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9462514 | pubmed:articleTitle | The duration of antigenic stimulation determines the fate of naive and effector T cells. | lld:pubmed |
| pubmed-article:9462514 | pubmed:affiliation | Basel Institute for Immunology, Switzerland. | lld:pubmed |
| pubmed-article:9462514 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9462514 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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