Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1998-3-16
|
pubmed:abstractText |
Bioassay-directed chromatographic fractionation of an ethyl acetate extract of the leaves of Acer okamotoanum using HIV-1 integrase afforded a new acylated flavonol glycoside, quercetin 3-O-(2",6"-O-digalloyl)-beta-D-galactopyranoside (1), together with six known flavonol glycosides and three known phenolic compounds. The structure of the new compound was determined by spectroscopic methods. The most active compounds were quercetin 3-O-(2"-galloyl)-alpha-L-arabinopyranoside (6) and 1, which exhibited IC50 values of 18.1 +/- 1.3 and 24.2 +/- 6.6 micrograms/mL, respectively, against HIV-1 integrase.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0163-3864
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
61
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
145-8
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9461665-Anti-HIV Agents,
pubmed-meshheading:9461665-Galactosides,
pubmed-meshheading:9461665-HIV Integrase Inhibitors,
pubmed-meshheading:9461665-HIV-1,
pubmed-meshheading:9461665-Humans,
pubmed-meshheading:9461665-Korea,
pubmed-meshheading:9461665-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9461665-Plant Leaves,
pubmed-meshheading:9461665-Plants, Medicinal,
pubmed-meshheading:9461665-Quercetin,
pubmed-meshheading:9461665-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:9461665-Spectrophotometry, Ultraviolet
|
pubmed:year |
1998
|
pubmed:articleTitle |
A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase.
|
pubmed:affiliation |
Division of Applied Science, Korea Institute of Science & Technology, Seoul, Korea.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|