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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-3-16
|
| pubmed:abstractText |
Litebamine N-homologues were easily prepared from laurolitsine, generally via three reaction steps (N-alkylation, solvolysis with 1 M NH4OAc under reflux, and the Mannich reaction) in more than 80% overall yield. Among the prepared compounds, N-propyl-, N-isobutyl-, and N-isopropylnorlitebamines exhibited moderate antiacetylcholinesterase activity (IC50 ca. 7.0 microM), while the corresponding N-metho salt of N-propylnorlitebamine showed potent activity (IC50 2.70 microM).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0163-3864
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
61
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
46-50
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9461651-Animals,
pubmed-meshheading:9461651-Cholinesterase Inhibitors,
pubmed-meshheading:9461651-Electric Organ,
pubmed-meshheading:9461651-Electrophorus,
pubmed-meshheading:9461651-Isoquinolines,
pubmed-meshheading:9461651-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9461651-Mannich Bases,
pubmed-meshheading:9461651-Plants,
pubmed-meshheading:9461651-Spectrophotometry, Ultraviolet
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Litebamine N-homologues: preparation and anti-acetylcholinesterase activity.
|
| pubmed:affiliation |
School of Pharmacy, College of Medicine, National Taiwan University, Republic of China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|