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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1998-3-23
|
| pubmed:databankReference | |
| pubmed:abstractText |
We report the identification of rat and human cDNAs for a type 1 membrane protein that contains a novel six-cysteine immunoglobulin-like domain and a mucin domain; it is named kidney injury molecule-1 (KIM-1). Structurally, KIM-1 is a member of the immunoglobulin gene superfamily most reminiscent of mucosal addressin cell adhesion molecule 1 (MAdCAM-1). Human KIM-1 exhibits homology to a monkey gene, hepatitis A virus cell receptor 1 (HAVcr-1), which was identified recently as a receptor for the hepatitis A virus. KIM-1 mRNA and protein are expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. In situ hybridization and immunohistochemistry revealed that KIM-1 is expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules. Structure and expression data suggest that KIM-1 is an epithelial cell adhesion molecule up-regulated in the cells, which are dedifferentiated and undergoing replication. KIM-1 may play an important role in the restoration of the morphological integrity and function to postischemic kidney.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0021-9258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
13
|
| pubmed:volume |
273
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4135-42
|
| pubmed:dateRevised |
2008-7-8
|
| pubmed:meshHeading |
pubmed-meshheading:9461608-Amino Acid Sequence,
pubmed-meshheading:9461608-Animals,
pubmed-meshheading:9461608-Base Sequence,
pubmed-meshheading:9461608-Cell Adhesion Molecules,
pubmed-meshheading:9461608-Cloning, Molecular,
pubmed-meshheading:9461608-Gene Expression Regulation,
pubmed-meshheading:9461608-Immunoglobulins,
pubmed-meshheading:9461608-Immunohistochemistry,
pubmed-meshheading:9461608-In Situ Hybridization,
pubmed-meshheading:9461608-Ischemia,
pubmed-meshheading:9461608-Kidney,
pubmed-meshheading:9461608-Male,
pubmed-meshheading:9461608-Membrane Proteins,
pubmed-meshheading:9461608-Molecular Sequence Data,
pubmed-meshheading:9461608-RNA, Messenger,
pubmed-meshheading:9461608-Rats,
pubmed-meshheading:9461608-Rats, Sprague-Dawley,
pubmed-meshheading:9461608-Recombinant Proteins,
pubmed-meshheading:9461608-Sequence Analysis, DNA,
pubmed-meshheading:9461608-Sequence Homology, Amino Acid,
pubmed-meshheading:9461608-Up-Regulation
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury.
|
| pubmed:affiliation |
Renal Unit, Medical Services, Massachusetts General Hospital East, Boston, Massachusetts 02129, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|