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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5353
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pubmed:dateCreated |
1998-3-5
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pubmed:abstractText |
The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1-negative allelic counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1-induced GvHD development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
pubmed-author:BishopT LTL,
pubmed-author:BloklandEE,
pubmed-author:EngelhardV HVH,
pubmed-author:GoulmyEE,
pubmed-author:HuntD FDF,
pubmed-author:MeadowsL MLM,
pubmed-author:OffringaRR,
pubmed-author:PonsRR,
pubmed-author:ReinhardusCC,
pubmed-author:ShabanowitzJJ,
pubmed-author:WantDD,
pubmed-author:den HaanJ MJM
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1054-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9461441-Alleles,
pubmed-meshheading:9461441-Amino Acid Sequence,
pubmed-meshheading:9461441-Bone Marrow Transplantation,
pubmed-meshheading:9461441-Cell Line,
pubmed-meshheading:9461441-Cell Line, Transformed,
pubmed-meshheading:9461441-Female,
pubmed-meshheading:9461441-Graft vs Host Disease,
pubmed-meshheading:9461441-HLA-A Antigens,
pubmed-meshheading:9461441-Histocompatibility Testing,
pubmed-meshheading:9461441-Humans,
pubmed-meshheading:9461441-Male,
pubmed-meshheading:9461441-Mass Spectrometry,
pubmed-meshheading:9461441-Minor Histocompatibility Antigens,
pubmed-meshheading:9461441-Minor Histocompatibility Loci,
pubmed-meshheading:9461441-Oligopeptides,
pubmed-meshheading:9461441-Phenotype,
pubmed-meshheading:9461441-Polymerase Chain Reaction,
pubmed-meshheading:9461441-Polymorphism, Genetic,
pubmed-meshheading:9461441-T-Lymphocytes, Cytotoxic
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pubmed:year |
1998
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pubmed:articleTitle |
The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism.
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pubmed:affiliation |
Department of Immunohematology and Bloodbank, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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