Linked Life Data

9461021

Source:http://linkedlifedata.com/resource/pubmed/id/9461021

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-2-19
pubmed:abstractText
An original system was developed to detect intercellular communication between epithelial cells of rat colon mucosa. Cell-to-cell communication was tested both in normal and in azoxymethane (AOM)-induced aberrant crypts in an attempt to identify chemically-induced modifications of cell properties. Stripes of unstained live tissue were superfused and oxygenated at room temperature and single cells at the top of the crypt were injected with fluorescent dyes. The bottom cells were filled in isolated crypts. Dyes injected into cells at the surface of the mucosa failed to diffuse to adjacent ones, whereas cells at the base of the crypts were dye-coupled. Surface cells from aberrant crypt foci (ACF) did not transfer the dye, therefore behaving like normal crypts. These results indicate that the pattern of intercellular communication between colon crypt cells changes as these cells differentiate and migrate to the top of the crypts and that the pattern of dye transfer between surface cells is maintained in ACF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Intercellular communication in normal and aberrant crypts of rat colon mucosa.
pubmed:affiliation
Dipartimento di Farmacologia Preclinica e Clinica, Firenze, Italy. bpassani@server1.pharm.unifi.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't