| pubmed-article:9458076 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9458076 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:9458076 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:9458076 | lifeskim:mentions | umls-concept:C0010843 | lld:lifeskim |
| pubmed-article:9458076 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9458076 | lifeskim:mentions | umls-concept:C2931822 | lld:lifeskim |
| pubmed-article:9458076 | lifeskim:mentions | umls-concept:C0286079 | lld:lifeskim |
| pubmed-article:9458076 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9458076 | pubmed:dateCreated | 1998-2-24 | lld:pubmed |
| pubmed-article:9458076 | pubmed:abstractText | The effect of the antiviral agent (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine (cidofovir) on the EBV-associated tumor nasopharyngeal carcinoma (NPC) was evaluated in NPC xenografts in athymic mice. Intratumoral injection arrested tumor growth within 1 week, and by 4 weeks, tumors regressed to 8-75% (39 +/- 33%) of the original size, whereas control tumors injected with PBS grew to 282 +/- 25% of the original size. Ganciclovir slowed but did not arrest or cause regression of tumor growth. A striking antitumor effect was also produced by systemic administration; at 4 weeks, tumors were 79 +/- 49% of the original size, compared with 635 +/- 91% for the controls. Widespread apoptosis was detected after treatment for 2-6 days in C15 as well as two other NPC xenografts, C17 and C18; the latter NPCs have mutations in the p53 gene. These data indicate that cidofovir induces rapid cell death through apoptosis in EBV-transformed epithelial cells. | lld:pubmed |
| pubmed-article:9458076 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458076 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458076 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9458076 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458076 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9458076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458076 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9458076 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9458076 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:9458076 | pubmed:author | pubmed-author:De ClercqEE | lld:pubmed |
| pubmed-article:9458076 | pubmed:author | pubmed-author:PaganoJ SJS | lld:pubmed |
| pubmed-article:9458076 | pubmed:author | pubmed-author:Raab-TraubNN | lld:pubmed |
| pubmed-article:9458076 | pubmed:author | pubmed-author:SadlerRR | lld:pubmed |
| pubmed-article:9458076 | pubmed:author | pubmed-author:NeytsJJ | lld:pubmed |
| pubmed-article:9458076 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9458076 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9458076 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:9458076 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9458076 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9458076 | pubmed:pagination | 384-8 | lld:pubmed |
| pubmed-article:9458076 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9458076 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9458076 | pubmed:articleTitle | The antiviral agent cidofovir [(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine] has pronounced activity against nasopharyngeal carcinoma grown in nude mice. | lld:pubmed |
| pubmed-article:9458076 | pubmed:affiliation | Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295, USA. | lld:pubmed |
| pubmed-article:9458076 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9458076 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9458076 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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