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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-2-24
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pubmed:abstractText |
The effect of the antiviral agent (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine (cidofovir) on the EBV-associated tumor nasopharyngeal carcinoma (NPC) was evaluated in NPC xenografts in athymic mice. Intratumoral injection arrested tumor growth within 1 week, and by 4 weeks, tumors regressed to 8-75% (39 +/- 33%) of the original size, whereas control tumors injected with PBS grew to 282 +/- 25% of the original size. Ganciclovir slowed but did not arrest or cause regression of tumor growth. A striking antitumor effect was also produced by systemic administration; at 4 weeks, tumors were 79 +/- 49% of the original size, compared with 635 +/- 91% for the controls. Widespread apoptosis was detected after treatment for 2-6 days in C15 as well as two other NPC xenografts, C17 and C18; the latter NPCs have mutations in the p53 gene. These data indicate that cidofovir induces rapid cell death through apoptosis in EBV-transformed epithelial cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
384-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9458076-Adolescent,
pubmed-meshheading:9458076-Animals,
pubmed-meshheading:9458076-Antiviral Agents,
pubmed-meshheading:9458076-Apoptosis,
pubmed-meshheading:9458076-Carcinoma,
pubmed-meshheading:9458076-Cytosine,
pubmed-meshheading:9458076-Drug Screening Assays, Antitumor,
pubmed-meshheading:9458076-Female,
pubmed-meshheading:9458076-Ganciclovir,
pubmed-meshheading:9458076-Genes, p53,
pubmed-meshheading:9458076-Herpesviridae Infections,
pubmed-meshheading:9458076-Herpesvirus 4, Human,
pubmed-meshheading:9458076-Humans,
pubmed-meshheading:9458076-Injections, Intralesional,
pubmed-meshheading:9458076-Mice,
pubmed-meshheading:9458076-Mice, Nude,
pubmed-meshheading:9458076-Nasopharyngeal Neoplasms,
pubmed-meshheading:9458076-Neoplasm Transplantation,
pubmed-meshheading:9458076-Organophosphorus Compounds,
pubmed-meshheading:9458076-Phosphonic Acids,
pubmed-meshheading:9458076-Tumor Virus Infections
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|
pubmed:year |
1998
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pubmed:articleTitle |
The antiviral agent cidofovir [(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine] has pronounced activity against nasopharyngeal carcinoma grown in nude mice.
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pubmed:affiliation |
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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