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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-3-23
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pubmed:databankReference |
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pubmed:abstractText |
We report the genomic structure and entire sequence of the fibroblast growth factor receptor 4 (FGFR4) gene. The gene spans approximately 11.3 kb. It is composed of 18 exons ranging in size from 71 bp to 600 bp. Exon-intron boundaries follow the GT/AG rule. Exon 1 is untranslated and preceded by structural elements characteristic of a TATA-free promoter. Although there are promoter motifs in intron 4 as well, there is currently no evidence of alternative transcription of FGFR4. Comparison of exon-intron boundaries of FGFR4 with those of FGFR1 and 3 reveals a remarkable degree of homology. With the exception of four, exon boundaries are at identical positions in all three receptor genes. Short tandem repeat polymorphisms (STRPs) were identified in introns 2 and 16 of FGFR4. The STRPs together with the sequence information will facilitate the rapid analysis of FGFR4 in those human disorders in which this gene can be considered a candidate.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0938-8990
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9457674-Amino Acid Sequence,
pubmed-meshheading:9457674-Base Sequence,
pubmed-meshheading:9457674-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:9457674-Exons,
pubmed-meshheading:9457674-Female,
pubmed-meshheading:9457674-Fibroblast Growth Factors,
pubmed-meshheading:9457674-Gene Library,
pubmed-meshheading:9457674-Humans,
pubmed-meshheading:9457674-Introns,
pubmed-meshheading:9457674-Male,
pubmed-meshheading:9457674-Molecular Sequence Data,
pubmed-meshheading:9457674-Pedigree,
pubmed-meshheading:9457674-Polymerase Chain Reaction,
pubmed-meshheading:9457674-Polymorphism, Genetic,
pubmed-meshheading:9457674-Receptor, Fibroblast Growth Factor, Type 4,
pubmed-meshheading:9457674-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:9457674-Sequence Alignment,
pubmed-meshheading:9457674-Sequence Analysis, DNA
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pubmed:year |
1998
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pubmed:articleTitle |
Genomic structure and complete sequence of the human FGFR4 gene.
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pubmed:affiliation |
Institut für Humangenetik, Justus-Liebig-Universität Giessen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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