Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-3-12
pubmed:abstractText
1. Partial deafferentation, based on peripheral nerve section or local anaesthetic blockade, has been reported to induce both immediate loss of responsiveness and/or immediate reorganization in receptive fields of neurones in the somatosensory system. In the present study, in anaesthetized cats, we have used a rapid, reversible deafferentation procedure based on cold block of the median nerve in order to evaluate quantitatively the response characteristics of cuneate neurones (n = 39) before, during and after partial deafferentation. 2. The first hypothesis tested was that cuneate neurones with input from ulnar or superficial radial nerve fields in the vicinity of the median nerve field should undergo, in association with median nerve blockade, an increased level of responsiveness to tactile stimuli within the ulnar or radial nerve zone, and an expansion of their cutaneous receptive fields. However, among eighteen cuneate neurones of this type, there was no evidence for any systematic enhancement of responsiveness nor, in at least sixteen of the eighteen neurones, any evidence for receptive field expansion. 3. The second hypothesis tested was that cuneate neurones whose input came from both the median nerve and another peripheral nerve source should undergo, in association with median nerve blockade, an increase in responsiveness to the remaining input and an expansion of the receptive field into the field of that remaining nerve source. However, in none of thirteen neurones of this type tested was there evidence of such a change. 4. The third hypothesis was that cuneate neurones whose control' receptive fields were within the median nerve zone of deafferentation should show an emergence of novel receptive fields and responsiveness from areas around the field of innervation of the median nerve. However, in none of eight neurones of this type was there evidence for such changes in adjacent skin areas. 5. In conclusion, with the use of cold block of the median nerve for partial deafferentation, the present study has confirmed previous findings of denervation-related loss of responsiveness in dorsal column nuclei neurones. The conflicting findings in studies of central nervous system plasticity indicate the need to understand better factors that do and do not lead to acute central changes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-1253869, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-13278885, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-1545866, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-1569467, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-1767621, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-1852162, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-1919668, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-1963250, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-2016636, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-3681711, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-3803522, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-497840, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-5723515, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-5860222, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-6481639, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-6505463, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-6646426, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-6661627, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-6747897, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-6824934, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-6832270, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-6875949, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-7142449, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-7205668, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-7251942, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-7891124, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-8000979, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-8014900, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-8266104, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-8429906, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-8484298, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-8592197, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-8742439, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-8844959, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-8867122, http://linkedlifedata.com/resource/pubmed/commentcorrection/9457651-954919
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
505 ( Pt 3)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
769-83
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Quantitative analysis of cuneate neurone responsiveness in the cat in association with reversible, partial deafferentation.
pubmed:affiliation
School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't