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pubmed-article:9457493pubmed:abstractText1. The effect of the acute or chronic oral administration of miglitol (Bay M 1099 alpha-glucosidase inhibitor) to non-insulin-dependent diabetic rats was studied. 2. The acute oral administration of miglitol (10 mg/kg b.w.) reduced significantly the increment of blood glucose after oral maltose (2 g/kg b.w.) overload (364 +/- 58 and 205 +/- 12 mmol/90 min, without and with miglitol respectively; P < 0.05). 3. Under chronic oral administration of miglitol (10 mg/kg b.w.), two days after the start of treatment the blood glucose dropped from 7.53 +/- 9.59 to 4.40 +/- 5.50 mmol/l. The plasma insulin, cholesterol, or triglycerides levels were not modified. 4. A significant reduction (P < 0.01) in water and food intake was observed. Normal rats values were not affected by miglitol treatment.lld:pubmed
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pubmed-article:9457493pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:9457493pubmed:articleTitleEffect of miglitol administration to non-insulin-dependent diabetic rats.lld:pubmed
pubmed-article:9457493pubmed:affiliationDepartamento de Fisiologia, Facultad de Medicina, Universidad de Extremadura Apartado, Badajoz, Spain.lld:pubmed
pubmed-article:9457493pubmed:publicationTypeJournal Articlelld:pubmed