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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-3-12
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pubmed:abstractText |
1. The effect of the acute or chronic oral administration of miglitol (Bay M 1099 alpha-glucosidase inhibitor) to non-insulin-dependent diabetic rats was studied. 2. The acute oral administration of miglitol (10 mg/kg b.w.) reduced significantly the increment of blood glucose after oral maltose (2 g/kg b.w.) overload (364 +/- 58 and 205 +/- 12 mmol/90 min, without and with miglitol respectively; P < 0.05). 3. Under chronic oral administration of miglitol (10 mg/kg b.w.), two days after the start of treatment the blood glucose dropped from 7.53 +/- 9.59 to 4.40 +/- 5.50 mmol/l. The plasma insulin, cholesterol, or triglycerides levels were not modified. 4. A significant reduction (P < 0.01) in water and food intake was observed. Normal rats values were not affected by miglitol treatment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0306-3623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9457493-1-Deoxynojirimycin,
pubmed-meshheading:9457493-Administration, Oral,
pubmed-meshheading:9457493-Animals,
pubmed-meshheading:9457493-Blood Glucose,
pubmed-meshheading:9457493-Diabetes Mellitus, Type 2,
pubmed-meshheading:9457493-Drug Administration Schedule,
pubmed-meshheading:9457493-Enzyme Inhibitors,
pubmed-meshheading:9457493-Glucosamine,
pubmed-meshheading:9457493-Hypoglycemic Agents,
pubmed-meshheading:9457493-Imino Pyranoses,
pubmed-meshheading:9457493-Male,
pubmed-meshheading:9457493-Rats,
pubmed-meshheading:9457493-Rats, Wistar
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pubmed:year |
1998
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pubmed:articleTitle |
Effect of miglitol administration to non-insulin-dependent diabetic rats.
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pubmed:affiliation |
Departamento de Fisiologia, Facultad de Medicina, Universidad de Extremadura Apartado, Badajoz, Spain.
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pubmed:publicationType |
Journal Article
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