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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1998-3-12
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pubmed:abstractText |
The 21-aminosteroid compounds are potent lipid peroxidation inhibitors belonging to a new class of antioxidants given the collective name of "lazaroids". They protect cells from oxidative damage induced by oxygen-based free radicals in a variety of in vitro and in vivo test systems. U-83836E is one of the second-generation lazaroids that are based on a non steroidal structure characterized by a ring portion of alpha-tocopherol bonded with various amine groups. We investigated the ability of U-83836E to reduce myocardial damage in rats undergoing left coronary artery occlusion for 60 min followed by 6 hours of reperfusion. This ischemia/reperfusion model produced wide heart necrosis, membrane lipid peroxidation, ventricular arrhythmias, tissue neutrophil infiltration and a marked decrease in endogenous antioxidants. Intravenous administration of U-83836E, (7.5, 15 and 30 mg/kg) at onset of reperfusion, reduced myocardial necrosis, expressed as a percentage of either the area at risk or the total left ventricle (p < 0.001), improved haemodynamic conditions by decreasing ventricular arrhythmias (p < 0.005), limited membrane lipid peroxidation (evaluated by assessing conjugated dienes, p < 0.001; and 4-hydroxynonenal, p < 0.001) restored the endogenous antioxidants vitamin E (p < 0.001), and superoxide dismutase (pt < 0.001). Furthermore, the lazaroid inhibited the derimental hydroxyl radical formation (p < 0.001), evaluated indirectly by a trapping agent and reduced heart neutrophil infiltration, measured by testing cardiac tissue elastase (p < 0.001) that is released from the stimulated granulocytes at the site of injury. These data suggest that this compound could be a new useful tool to study the mechanisms of oxidative damage during myocardial infarction.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-hydroxy-2-nonenal,
http://linkedlifedata.com/resource/pubmed/chemical/Aldehydes,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Chromans,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyl Radical,
http://linkedlifedata.com/resource/pubmed/chemical/Pancreatic Elastase,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/U 78517F,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1071-5762
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
577-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9455693-Aldehydes,
pubmed-meshheading:9455693-Animals,
pubmed-meshheading:9455693-Antioxidants,
pubmed-meshheading:9455693-Cardiovascular System,
pubmed-meshheading:9455693-Chromans,
pubmed-meshheading:9455693-Free Radical Scavengers,
pubmed-meshheading:9455693-Hydroxyl Radical,
pubmed-meshheading:9455693-Male,
pubmed-meshheading:9455693-Myocardial Infarction,
pubmed-meshheading:9455693-Myocardial Reperfusion Injury,
pubmed-meshheading:9455693-Pancreatic Elastase,
pubmed-meshheading:9455693-Piperazines,
pubmed-meshheading:9455693-Rats,
pubmed-meshheading:9455693-Rats, Sprague-Dawley,
pubmed-meshheading:9455693-Superoxide Dismutase,
pubmed-meshheading:9455693-Vitamin E
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pubmed:year |
1997
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pubmed:articleTitle |
Antioxidant activity of U-83836E, a second generation lazaroid, during myocardial ischemia/reperfusion injury.
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pubmed:affiliation |
Institute of Pharmacology, School of Medicine, University of Messina, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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