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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-2-20
|
| pubmed:databankReference | |
| pubmed:abstractText |
The eotaxin receptor (CCR3) is a CD4-associated coreceptor for human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2). By comparison with other chemokine receptors, such as CCR5 and CXCR4, the primary sequences of human CCR3 and its rhesus macaque homolog were markedly different in their extracellular domains. Human CD4+ cells expressing CCR3 from either human or macaque origin could be infected by HIV-2, with apparently similar efficiency, but only cells expressing human CCR3 could be infected by HIV-1. It suggests that HIV-1 and HIV-2 envelope proteins interact differently with the CCR3 coreceptor HIV-1 could infect cells expressing chimeric human/macaque CCR3 bearing either the first and second, or the third and fourth extracellular domains of human CCR3. As previously observed for CCR5, there seems to be a certain functional redundancy between domains supporting the coreceptor activity of CCR3. In spite of their close genetic relationship to HIV-2, two macaque simian immunodeficiency virus strains were apparently unable to use the CCR3 coreceptor from either human or simian origin.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0042-6822
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
240
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
213-20
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9454694-Amino Acid Sequence,
pubmed-meshheading:9454694-Animals,
pubmed-meshheading:9454694-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9454694-Cell Line,
pubmed-meshheading:9454694-Cercopithecus aethiops,
pubmed-meshheading:9454694-Chimera,
pubmed-meshheading:9454694-HIV-1,
pubmed-meshheading:9454694-HIV-2,
pubmed-meshheading:9454694-HeLa Cells,
pubmed-meshheading:9454694-Humans,
pubmed-meshheading:9454694-Macaca mulatta,
pubmed-meshheading:9454694-Molecular Sequence Data,
pubmed-meshheading:9454694-Protein Structure, Tertiary,
pubmed-meshheading:9454694-Receptors, CCR3,
pubmed-meshheading:9454694-Receptors, Chemokine,
pubmed-meshheading:9454694-Sequence Alignment,
pubmed-meshheading:9454694-Sequence Homology, Amino Acid,
pubmed-meshheading:9454694-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:9454694-Simian immunodeficiency virus,
pubmed-meshheading:9454694-Substrate Specificity
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
The rhesus macaque CCR3 chemokine receptor is a cell entry cofactor for HIV-2, but not for HIV-1.
|
| pubmed:affiliation |
INSERM U332, Institut Cochin de Génétique Moléculaire (ICGM), Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|