Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-2-12
pubmed:abstractText
This study examined apoptotic cell death associated with Shiga-like toxin (Stx)-producing Escherichia coli. Renal cortices from three children with postenteropathic hemolytic-uremic syndrome (HUS) and from mice infected with E. coli O157:H7 and pediatric renal tubular epithelial cells stimulated with Stx and E. coli O157:H7 extracts were examined for apoptotic changes. Apoptotic cells were detected by terminal dUTP nick end labeling of tubuli and glomeruli from HUS patients and from mice inoculated with Stx-2-positive and Stx-negative strains. Apoptosis was more extensive and severe ultramorphological nuclear and cytoplasmic changes were seen in the Stx-2-positive group. Stx caused DNA fragmentation and ultramorphological changes indicating apoptosis in cultured pediatric tubular cells. DNA fragmentation increased when cells were pre-stimulated with tumor necrosis factor alpha. Polymyxin extracts from Stx-2-positive and Stx-negative strains induced DNA fragmentation, but only extracts from Stx-2-positive strains caused ultramorphological changes and extensive DNA fragmentation. The results indicate that HUS is accompanied by increased apoptosis of kidney cells and that bacterial factors, possibly together with host cytokines in vivo, may activate apoptotic tissue injury.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-1333300, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-1400587, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-14228505, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-1572394, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-1607689, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-1614548, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-1670788, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-1901867, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-1937774, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-2196227, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-2254023, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-2492525, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-2647865, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-2674572, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-2768263, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3044997, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3053764, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3056169, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3301891, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3316033, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3510166, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3512443, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3535529, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3663122, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3886804, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-3908473, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-4561027, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-6186379, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-6339403, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-6375582, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-6894922, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-7012172, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-7537254, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-7594687, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-7609755, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-7673744, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-7698800, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-8082754, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-8221667, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-8227326, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-8335369, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-8340376, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-8463896, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-8627068, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-8670890, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-8747107, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-9028945, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-9041333, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-9052384, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-9083293, http://linkedlifedata.com/resource/pubmed/commentcorrection/9453620-9220458
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
636-44
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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