| pubmed-article:9453602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C0023343 | lld:lifeskim |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9453602 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9453602 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9453602 | pubmed:dateCreated | 1998-2-12 | lld:pubmed |
| pubmed-article:9453602 | pubmed:abstractText | Advanced stages of mycobacterial diseases such as leprosy and tuberculosis are characterized by a loss of T-cell function. The basis of this T-cell dysfunction is not well understood. The present report demonstrates major alterations in the expression of signal transduction molecules in T cells of leprosy patients. These alterations were most frequently observed in lepromatous leprosy (LL) patients. Of 29 LL patients, 69% had decreased T-cell receptor zeta-chain expression, 48% had decreased p56(lck) tyrosine kinase, and 63% had a loss of nuclear transcription factor NF-kappaB p65. An electrophoretic mobility shift assay with the gamma interferon core promoter region revealed a loss of the Th1 DNA-binding pattern in LL patients. In contrast, tuberculoid leprosy patients had only minor signal transduction alterations. These novel findings might improve our understanding of the T-cell dysfunction observed in leprosy and other infectious diseases and consequently might lead to better immunologic evaluation of patients. | lld:pubmed |
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| pubmed-article:9453602 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9453602 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9453602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9453602 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9453602 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:GhoseSS | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:LongoD LDL | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:SaraviaNN | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:FalabellaRR | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:HarveyL KLK | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:OchoaA CAC | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:AlvordW GWG | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:ValderramaLL | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:OchoaM TMT | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:MorenoL HLH | lld:pubmed |
| pubmed-article:9453602 | pubmed:author | pubmed-author:ZeaA HAH | lld:pubmed |
| pubmed-article:9453602 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9453602 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:9453602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9453602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9453602 | pubmed:pagination | 499-504 | lld:pubmed |
| pubmed-article:9453602 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9453602 | pubmed:meshHeading | pubmed-meshheading:9453602-... | lld:pubmed |
| pubmed-article:9453602 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9453602 | pubmed:articleTitle | Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy. | lld:pubmed |
| pubmed-article:9453602 | pubmed:affiliation | Immunotherapy Program, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, New Orleans 70112, USA. azea@lsumc.edu | lld:pubmed |
| pubmed-article:9453602 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9453602 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9453602 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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