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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-2-12
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pubmed:abstractText |
Advanced stages of mycobacterial diseases such as leprosy and tuberculosis are characterized by a loss of T-cell function. The basis of this T-cell dysfunction is not well understood. The present report demonstrates major alterations in the expression of signal transduction molecules in T cells of leprosy patients. These alterations were most frequently observed in lepromatous leprosy (LL) patients. Of 29 LL patients, 69% had decreased T-cell receptor zeta-chain expression, 48% had decreased p56(lck) tyrosine kinase, and 63% had a loss of nuclear transcription factor NF-kappaB p65. An electrophoretic mobility shift assay with the gamma interferon core promoter region revealed a loss of the Th1 DNA-binding pattern in LL patients. In contrast, tuberculoid leprosy patients had only minor signal transduction alterations. These novel findings might improve our understanding of the T-cell dysfunction observed in leprosy and other infectious diseases and consequently might lead to better immunologic evaluation of patients.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-1357030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-1423592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-1465616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-1542667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-1925582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-2042708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-2521244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-2535060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-2903212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-2942780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-3257577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-3278811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-6216407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-6228349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-7506419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-7516328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-7523497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-7590888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-8006444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-8096699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-8162435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-8163933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-8187083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-8242612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-8242613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-8704179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-8915730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-9815928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9453602-9816103
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0019-9567
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pubmed:author |
pubmed-author:AlvordW GWG,
pubmed-author:FalabellaRR,
pubmed-author:GhoseSS,
pubmed-author:HarveyL KLK,
pubmed-author:LongoD LDL,
pubmed-author:MorenoL HLH,
pubmed-author:OchoaA CAC,
pubmed-author:OchoaM TMT,
pubmed-author:SaraviaNN,
pubmed-author:ValderramaLL,
pubmed-author:ZeaA HAH
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
499-504
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9453602-Adult,
pubmed-meshheading:9453602-Cytokines,
pubmed-meshheading:9453602-DNA,
pubmed-meshheading:9453602-Female,
pubmed-meshheading:9453602-Humans,
pubmed-meshheading:9453602-Leprosy,
pubmed-meshheading:9453602-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:9453602-Male,
pubmed-meshheading:9453602-Membrane Proteins,
pubmed-meshheading:9453602-NF-kappa B,
pubmed-meshheading:9453602-Receptors, Antigen, T-Cell,
pubmed-meshheading:9453602-Signal Transduction,
pubmed-meshheading:9453602-T-Lymphocytes
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pubmed:year |
1998
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pubmed:articleTitle |
Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy.
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pubmed:affiliation |
Immunotherapy Program, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, New Orleans 70112, USA. azea@lsumc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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