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rdf:type |
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lifeskim:mentions |
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0036751,
umls-concept:C0086168,
umls-concept:C0152314,
umls-concept:C0205276,
umls-concept:C0299247,
umls-concept:C0442805,
umls-concept:C0449560,
umls-concept:C1280500,
umls-concept:C1415803
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pubmed:issue |
2
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pubmed:dateCreated |
1998-2-24
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pubmed:abstractText |
We examined the effect of kindling on serotonergic neurotransmission in the hippocampus by measuring serotonin (5-HT) release and uptake in hippocampal synaptosomes and 5-HT1A and 5-HT4 receptor subtypes during and at different times after electrical kindling of the dentate gyrus. Using quantitative receptor autoradiography, we found that binding of 8-[3H]hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) to 5-HT1A receptors was selectively increased by 20% on average (p < 0.05) in the dentate gyrus of the stimulated and contralateral hippocampus 2 days after stage 2 (stereotypes and occasional retraction of a forelimb) and by 100% on average (p < 0.05) 1 week after stage 5 (tonic-clonic seizures) compared with sham-stimulated rats. A 20% increase (p < 0.05) was observed 1 month after the last generalized seizure. No changes were found after a single afterdischarge. 5-HT4 receptors, which colocalize with 5-HT1A receptors on hippocampal neurons, were not modified in kindled tissue. [3H]5-HT uptake and its release as well as the 5-HT1B autoreceptor function did not differ from shams in hippocampal synaptosomes at stages 2 and 5. Systemic administration of 100 and 1,000 microg kg(-1) 8-OH-DPAT or 1,000 microg kg(-1) WAY-100,635, 30 min before each electrical stimulation, did not significantly alter kindling progression or the occurrence of stage 5 seizures in fully kindled rats. The changes in 5-HT1A receptor density in the dentate gyrus are part of the plastic modifications occurring during kindling and may contribute to modulating tissue hyperexcitability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxanes,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT4,
http://linkedlifedata.com/resource/pubmed/chemical/SB 207710,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium,
http://linkedlifedata.com/resource/pubmed/chemical/WAY 100635
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-3042
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
850-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9453582-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:9453582-Animals,
pubmed-meshheading:9453582-Cerebral Cortex,
pubmed-meshheading:9453582-Dentate Gyrus,
pubmed-meshheading:9453582-Dioxanes,
pubmed-meshheading:9453582-Electric Stimulation,
pubmed-meshheading:9453582-Functional Laterality,
pubmed-meshheading:9453582-Hippocampus,
pubmed-meshheading:9453582-Iodine Radioisotopes,
pubmed-meshheading:9453582-Kindling, Neurologic,
pubmed-meshheading:9453582-Male,
pubmed-meshheading:9453582-Neurons,
pubmed-meshheading:9453582-Piperazines,
pubmed-meshheading:9453582-Piperidines,
pubmed-meshheading:9453582-Pyridines,
pubmed-meshheading:9453582-Radioligand Assay,
pubmed-meshheading:9453582-Rats,
pubmed-meshheading:9453582-Rats, Sprague-Dawley,
pubmed-meshheading:9453582-Receptors, Serotonin,
pubmed-meshheading:9453582-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:9453582-Receptors, Serotonin, 5-HT4,
pubmed-meshheading:9453582-Serotonin,
pubmed-meshheading:9453582-Serotonin Antagonists,
pubmed-meshheading:9453582-Synapses,
pubmed-meshheading:9453582-Tritium
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pubmed:year |
1998
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pubmed:articleTitle |
Lasting increase in serotonin 5-HT1A but not 5-HT4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects.
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pubmed:affiliation |
Laboratory of Receptor Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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