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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1998-4-6
|
| pubmed:abstractText |
The concept of Hydrophilic Sphere Stabilization, or Hydrophobic Shielding, has been postulated in the synthesis of biocompatible contrast agents in vascular imaging. To improve the safety of these polyiodinated agents, interactions with protein hydrophobic sites in biomacromolecules should be kept as low as possible. In order to evaluate the level of interactions with proteins, we have selected the serine proteinase Elastase, in presence of Iobitridol (Xenetix), as a model.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0724-8741
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1713-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9453058-Animals,
pubmed-meshheading:9453058-Binding Sites,
pubmed-meshheading:9453058-Contrast Media,
pubmed-meshheading:9453058-Fourier Analysis,
pubmed-meshheading:9453058-Iohexol,
pubmed-meshheading:9453058-Models, Biological,
pubmed-meshheading:9453058-Pancreatic Elastase,
pubmed-meshheading:9453058-Swine,
pubmed-meshheading:9453058-X-Ray Diffraction
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Study of the complex between the contrast agent Iobitridol (Xenetix) and Elastase (PPE): a model for hydrophobic site protection in drug-protein interactions.
|
| pubmed:affiliation |
Chimie Structurale Biomoleculaire (URA-1430 CNRS, Bobigny, France. prange@lure.u-psud.fr
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|