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pubmed:abstractText |
Based on the histologic findings of fully developed lesions, leukocytoclastic vasculitis has been regarded as the histologic criterion for differentiating urticarial vasculitis from urticaria. Nevertheless, because the early lesions have not been examined histologically, the key biological events leading to the development of leukocytoclastic vasculitis remain unknown. To address this issue, urticarial vasculitis lesions induced by physical exercise were sequentially examined histologically and immunohistochemically in a patient over the course of 24 hours. Serum levels of various cytokines also were determined in parallel.
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