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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-3-18
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pubmed:abstractText |
The mammalian genome encodes at least nine different members of the ClC family of chloride channels. So far only two of them could be localized on a cellular level in the kidney. We now report on the precise intrarenal localization of the mRNAs coding for the chloride channels ClC-2, ClC-3 and ClC-5. Expression of ClC-2 mRNA, encoding a swelling-activated chloride channel, could be demonstrated in the S3 segment of the proximal tubule. The chloride channel ClC-3 mRNA and ClC-5 mRNA, coding for a chloride channel mutated in kidney stone disease, were both expressed in intercalated cells of the connecting tubule and collecting duct. Whereas ClC-3 mRNA expression was most prominent in the cortex of rat kidneys, ClC-5 mRNA was expressed from the cortex through the upper portion of the inner medulla. A detailed analysis revealed that ClC-3 was expressed by type B intercalated cells, whereas ClC-5 was expressed by type A intercalated cells. These findings have important implications for the pathogenesis of hereditary kidney stone disease caused by mutations in the CLCN5 gene.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-1311421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-1314040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-1334533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-1373501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-1379744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-1659664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-1718002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-1908057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-2155536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-3942227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-3985156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-7539496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-7680033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-7730971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-7814604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8041726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8069296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8155321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8368343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8537381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8543009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8559248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8594886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8626585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8773474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-8944727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-9062355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-9176380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449697-9407504
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
635-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9449697-Animals,
pubmed-meshheading:9449697-Chloride Channels,
pubmed-meshheading:9449697-Disease Models, Animal,
pubmed-meshheading:9449697-Epithelial Cells,
pubmed-meshheading:9449697-Kidney,
pubmed-meshheading:9449697-Kidney Calculi,
pubmed-meshheading:9449697-Kidney Tubules, Proximal,
pubmed-meshheading:9449697-Male,
pubmed-meshheading:9449697-Mutation,
pubmed-meshheading:9449697-Osmolar Concentration,
pubmed-meshheading:9449697-RNA, Messenger,
pubmed-meshheading:9449697-Rats,
pubmed-meshheading:9449697-Rats, Sprague-Dawley
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pubmed:year |
1998
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pubmed:articleTitle |
The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells.
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pubmed:affiliation |
Medical Research Center, Klinikum Mannheim, University of Heidelberg, D-68167 Mannheim, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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