Linked Life Data

9449538

Source:http://linkedlifedata.com/resource/pubmed/id/9449538

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1998-2-19
pubmed:abstractText
There is a need to perform pharmacokinetic studies in the pediatric population utilizing antiretroviral drugs, which have shown effectiveness for the treatment of human immunodeficiency virus (HIV). In order to establish a relationship between efficacy and toxicity, we need to detect and quantitate these antiretroviral nucleosides and their metabolites at the intracellular level. Micellar electrokinetic capillary chromatography (MECC) was used for the separation of five nucleotides: cytidine triphosphate (CTP), adenosine triphosphate (ATP), thymidine triphosphate (TTP), guanosine triphosphate (GTP) and azidothymidine triphosphate (AZT-TP). Attomoles of these nucleotides were satisfactorily resolved in short run times with high peak efficiencies. In addition, nanoliters of sample volume were used to perform the analysis using ultraviolet (UV) detection at 254 nm.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0145-5680
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1051-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Azidothymidine triphosphate determination using micellar electrokinetic capillary chromatography.
pubmed:affiliation
University of Puerto Rico, Department of Pharmaceutical Sciences, School of Pharmacy, San Juan 00936, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.