| pubmed-article:9449535 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9449535 | lifeskim:mentions | umls-concept:C1265549 | lld:lifeskim |
| pubmed-article:9449535 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:9449535 | lifeskim:mentions | umls-concept:C1327413 | lld:lifeskim |
| pubmed-article:9449535 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9449535 | lifeskim:mentions | umls-concept:C0276498 | lld:lifeskim |
| pubmed-article:9449535 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9449535 | pubmed:dateCreated | 1998-2-19 | lld:pubmed |
| pubmed-article:9449535 | pubmed:abstractText | The response of caprine macrophages to exposure to caprine arthritis-encephalitis virus (CAEV) and lipopolysaccharide (LPS) was investigated in female Nubian and Nubian crossbreed of goats. Macrophages were matured in vitro from monocytes isolated from blood of control and CAEV-infected goats and the concentrations of tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) in culture supernatant after exposure of cells to LPS and virus were assayed. Though barely detectable in unstimulated cells, TNF-alpha and IL-6 levels showed peak values of 420 +/- 28 to 530 +/- 32 and 70 +/- 27 to 93 +/- 29, respectively, in supernatants of control goat cells [corrected], remaining high through 24 hrs. post treatment with LPS stimulation. Exposure of these control goat cells [corrected] to virus induced lower secretions (p<0.05) of the cytokines. The peak values occurred between 6 and 12 hrs. post treatment with LPS or virus. Cells prepared from virus-infected goats and treated with the mitogen or virus showed significantly (p<0.05) lower response than those from control goats. The present results suggest a dysregulation, possibly downregulation of the production of both cytokines in macrophages of goats chronically diseased by lentivirus infection. | lld:pubmed |
| pubmed-article:9449535 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449535 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449535 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9449535 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449535 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9449535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449535 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9449535 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9449535 | pubmed:issn | 0145-5680 | lld:pubmed |
| pubmed-article:9449535 | pubmed:author | pubmed-author:AdeyemoOO | lld:pubmed |
| pubmed-article:9449535 | pubmed:author | pubmed-author:LanH CHC | lld:pubmed |
| pubmed-article:9449535 | pubmed:author | pubmed-author:BeyM RMR | lld:pubmed |
| pubmed-article:9449535 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9449535 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:9449535 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9449535 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9449535 | pubmed:pagination | 1031-7 | lld:pubmed |
| pubmed-article:9449535 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:meshHeading | pubmed-meshheading:9449535-... | lld:pubmed |
| pubmed-article:9449535 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9449535 | pubmed:articleTitle | Cytokine production in vitro by macrophages of goats with caprine arthritis-encephalitis. | lld:pubmed |
| pubmed-article:9449535 | pubmed:affiliation | Department of Pathobiology, School of Veterinary Medicine, Tuskegee University, AL 36088, USA. | lld:pubmed |
| pubmed-article:9449535 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9449535 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
