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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-4-2
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pubmed:abstractText |
Electron cryomicroscopy and icosahedral reconstruction are used to obtain the three-dimensional structure of the 1250-A-diameter herpesvirus B-capsid. The centers and orientations of particles in focal pairs of 400-kV, spot-scan micrographs are determined and iteratively refined by common-lines-based local and global refinement procedures. We describe the rationale behind choosing shared-memory multiprocessor computers for executing the global refinement, which is the most computationally intensive step in the reconstruction procedure. This refinement has been implemented on three different shared-memory supercomputers. The speedup and efficiency are evaluated by using test data sets with different numbers of particles and processors. Using this parallel refinement program, we refine the herpesvirus B-capsid from 355-particle images to 13-A resolution. The map shows new structural features and interactions of the protein subunits in the three distinct morphological units: penton, hexon, and triplex of this T = 16 icosahedral particle.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-1370343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-14019094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-1733107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-1846047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-2038034,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-3471122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-3829124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-4399207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-7473720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-7474170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-7583656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-7643390,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-8052847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-8087554,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-8742733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-8742746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-9052786,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9449358-9262023
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
576-88
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1998
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pubmed:articleTitle |
Refinement of herpesvirus B-capsid structure on parallel supercomputers.
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pubmed:affiliation |
Texas Center for Advanced Molecular Computation, University of Houston, 77204-3476, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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