Linked Life Data

9448369

Source:http://linkedlifedata.com/resource/pubmed/id/9448369

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-3-19
pubmed:abstractText
Despite considerable sparing of function following some forms of early brain disease, neural plasticity is far from complete. Many children with early brain insults, including those who sustain traumatic brain injury (TBI), are susceptible to both immediate and long-term neurobehavioral impairments. To introduce this symposium, the present article reviews existing research on the effects of 3 age-related factors on outcomes: age at injury, time since injury, and age at testing. Research findings support the hypothesis that development is more adversely affected the younger the child at the time of brain insult. Although we know less about how outcomes are related to the other developmental factors, there is little evidence that sequelae resolve with age. Potential brain mechanisms responsible for age-related differences are explored and methodological problems are considered. Emphasis is placed on the importance of prospective designs, measurement of developmental change, comprehensive assessments of outcome, and evaluation of factors contributing to variability in outcomes, such as premorbid status, type of brain injury, and environmental influences. Papers in this series demonstrate the utility of these methods and shed new light on developmental processes associated with childhood brain insults.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1355-6177
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
555-67
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Age-related differences in outcomes following childhood brain insults: an introduction and overview.
pubmed:affiliation
Case Western Reserve University School of Medicine, Cleveland, OH, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review