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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-3-11
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pubmed:abstractText |
Ig class switching usually occurs as a consequence of cognate interactions between antigen-specific B cells and CD4(+) alphabeta T cells. Vesicular stomatitis virus (VSV) infection of immunocompetent mice induces a rapid T-independent neutralizing IgM response followed by a long-lived T-dependent IgG response. Surprisingly, alphabeta T cell-deficient (TCRalpha-/-) mice also produced neutralizing IgG antibodies when infected with live VSV or with a recombinant vaccinia virus expressing the VSV glycoprotein (Vacc-IND-G), but not when immunized with UV-inactivated VSV (UV-VSV). The neutralizing IgG responses did not require the presence of NK cells or complement, but were crucially dependent on IFN-gamma and were predominantly of the IgG2a isotype. IgG production depended on residual CD3(+) non-alphabeta T cell populations present in the TCRalpha-/- mice, which produced IFN-gamma upon in vitro stimulation. A key role for gammadelta T cells was confirmed by the fact that TCRbeta-/- mice also generated strong neutralizing IgG responses to VSV, whereas TCRbeta-/-delta-/- mice produced very low titers. The neutralizing IgG responses of TCRalpha-/- mice were accompanied by the development of memory B cells, but not by antigen-specific germinal center (GC) formation. Thus, during viral infection of alphabeta T cell-deficient mice, gammadelta T cells may provide the signals that are required for isotype switching.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-1359428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-13641571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-1604321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-1693082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-1739427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-1755944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-1850779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-2435794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-2468501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-2542591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-2553771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-2981435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-3007610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-3199074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-3794607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-4190338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-4315954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-6154097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-6185583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-6259260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-6886424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7040212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7512589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7542009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7595206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7612238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7910138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7910641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7930564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7947457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-7991563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8011279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8177322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8208291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8248784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8389912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8442856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8476565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8553069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8627153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8640864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8642335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8642336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8684487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8766567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8805272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8879191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9448302-8879212
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1160-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9448302-Animals,
pubmed-meshheading:9448302-Antibodies, Viral,
pubmed-meshheading:9448302-Complement Activation,
pubmed-meshheading:9448302-Germinal Center,
pubmed-meshheading:9448302-Immunoglobulin Class Switching,
pubmed-meshheading:9448302-Immunoglobulin G,
pubmed-meshheading:9448302-Interferon-gamma,
pubmed-meshheading:9448302-Killer Cells, Natural,
pubmed-meshheading:9448302-Mice,
pubmed-meshheading:9448302-Mice, Inbred C57BL,
pubmed-meshheading:9448302-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:9448302-Rhabdoviridae Infections,
pubmed-meshheading:9448302-Stomatitis,
pubmed-meshheading:9448302-T-Lymphocytes,
pubmed-meshheading:9448302-Vesicular stomatitis Indiana virus
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pubmed:year |
1998
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pubmed:articleTitle |
Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection.
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pubmed:affiliation |
Institute of Experimental Immunology, Department of Pathology, University of Zürich, Schmelzbergstrasse 12, CH-8091, Zürich, Switzerland. kmaloy@pathol.unizh.ch
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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