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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-2-18
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pubmed:abstractText |
Chemokine receptors are coupled to G-proteins and their activation results in prominent changes in cell migration and growth. The downstream signaling pathways that mediate these effects of chemokines are largely uncharacterized. Macrophage inflammatory protein 1 beta (MIP 1 beta) binding to its cognate receptor CCR5 resulted in activation of the related adhesion focal tyrosine kinase (RAFTK), with subsequent activation of the cytoskeletal protein paxillin and the down-stream transcriptional activators, c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and p38 mitogen-activated protein (MAP) kinase. Inhibition of RAFTK by a dominant-negative kinase mutant markedly attenuated JNK/ SAPK activity. Thus, RAFTK appears to provide a functional "bridge" for the transmission of CCR5 receptor signaling to the cytoskeleton and nucleus, primary sites of chemotaxis and growth regulation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/PXN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Paxillin,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptk2b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pxn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
791-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9446638-Animals,
pubmed-meshheading:9446638-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9446638-Chemokine CCL4,
pubmed-meshheading:9446638-Cytoskeletal Proteins,
pubmed-meshheading:9446638-Enzyme Activation,
pubmed-meshheading:9446638-Focal Adhesion Kinase 2,
pubmed-meshheading:9446638-Humans,
pubmed-meshheading:9446638-Immunosorbent Techniques,
pubmed-meshheading:9446638-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9446638-Lymphoma,
pubmed-meshheading:9446638-Macrophage Inflammatory Proteins,
pubmed-meshheading:9446638-Mice,
pubmed-meshheading:9446638-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9446638-Paxillin,
pubmed-meshheading:9446638-Phosphoproteins,
pubmed-meshheading:9446638-Phosphorylation,
pubmed-meshheading:9446638-Protein-Tyrosine Kinases,
pubmed-meshheading:9446638-Receptors, CCR5,
pubmed-meshheading:9446638-Transfection,
pubmed-meshheading:9446638-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK.
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pubmed:affiliation |
Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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