| pubmed-article:944586 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:944586 | lifeskim:mentions | umls-concept:C0085080 | lld:lifeskim |
| pubmed-article:944586 | lifeskim:mentions | umls-concept:C0032207 | lld:lifeskim |
| pubmed-article:944586 | lifeskim:mentions | umls-concept:C0009429 | lld:lifeskim |
| pubmed-article:944586 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:944586 | lifeskim:mentions | umls-concept:C0034538 | lld:lifeskim |
| pubmed-article:944586 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:944586 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:944586 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:944586 | pubmed:dateCreated | 1976-8-2 | lld:pubmed |
| pubmed-article:944586 | pubmed:abstractText | Cis-dichlorobis(cyclopentylamine)platinum II (DBCP) belongs to the group of platinum complexes which have recently been reported to have anti-tumour activity. Its cytotoxic activity in CHO cells is not cell-age-dependent, but enhancement of the effect of ionizing radiation is both dose-and cell cycle phase-dependent. In asynchronous cell populations DBCP acts as a dose-modifying factor for ionizing radiation. Doses of DBCP reducing survival of CHO cells to 26% and 4% applied 1 h before irradiation reduce the Do value of radiation dose-survival curves by factors of 1-34 and 1-59 respectively. In synchronized CHO populations enhancement by DBCP of the effect of radiation is most pronounced in G1 and in late S while it is reduced in mid-S. Possible mechanisms of DBCP-radiation interaction are discussed. | lld:pubmed |
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| pubmed-article:944586 | pubmed:language | eng | lld:pubmed |
| pubmed-article:944586 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:944586 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:944586 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:944586 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:944586 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:944586 | pubmed:author | pubmed-author:NiasA HAH | lld:pubmed |
| pubmed-article:944586 | pubmed:author | pubmed-author:SzumielII | lld:pubmed |
| pubmed-article:944586 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:944586 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:944586 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:944586 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:944586 | pubmed:pagination | 450-8 | lld:pubmed |
| pubmed-article:944586 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:944586 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:944586 | pubmed:articleTitle | The effect of combined treatment with a platinum complex and ionizing radiation on chinese hamster ovary cells in vitro. | lld:pubmed |
| pubmed-article:944586 | pubmed:publicationType | Journal Article | lld:pubmed |
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