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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1976-8-2
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pubmed:abstractText |
Cis-dichlorobis(cyclopentylamine)platinum II (DBCP) belongs to the group of platinum complexes which have recently been reported to have anti-tumour activity. Its cytotoxic activity in CHO cells is not cell-age-dependent, but enhancement of the effect of ionizing radiation is both dose-and cell cycle phase-dependent. In asynchronous cell populations DBCP acts as a dose-modifying factor for ionizing radiation. Doses of DBCP reducing survival of CHO cells to 26% and 4% applied 1 h before irradiation reduce the Do value of radiation dose-survival curves by factors of 1-34 and 1-59 respectively. In synchronized CHO populations enhancement by DBCP of the effect of radiation is most pronounced in G1 and in late S while it is reduced in mid-S. Possible mechanisms of DBCP-radiation interaction are discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-13772379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-13980637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-163094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-167787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-4132591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-4349502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-4472190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-4641756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-4652593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-4826500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-5689085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/944586-5782119
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
450-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:944586-Animals,
pubmed-meshheading:944586-Cell Survival,
pubmed-meshheading:944586-Cells, Cultured,
pubmed-meshheading:944586-Chromosome Aberrations,
pubmed-meshheading:944586-Cricetinae,
pubmed-meshheading:944586-Dose-Response Relationship, Drug,
pubmed-meshheading:944586-Dose-Response Relationship, Radiation,
pubmed-meshheading:944586-Female,
pubmed-meshheading:944586-Mitosis,
pubmed-meshheading:944586-Ovary,
pubmed-meshheading:944586-Platinum,
pubmed-meshheading:944586-Radiation Effects,
pubmed-meshheading:944586-Time Factors
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pubmed:year |
1976
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pubmed:articleTitle |
The effect of combined treatment with a platinum complex and ionizing radiation on chinese hamster ovary cells in vitro.
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pubmed:publicationType |
Journal Article
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