Linked Life Data

9443927

Source:http://linkedlifedata.com/resource/pubmed/id/9443927

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-2-20
pubmed:abstractText
Receptor autoradiography with the Y2 receptor ligand 125I-peptide YY3-36 and in situ hybridization were applied to investigate changes in neuropeptide tyrosine-Y2 receptor expression after kainic acid-induced recurrent seizures in the rat hippocampus. In the strata oriens and radiatum of CA1 to CA3, which are densely innervated by Y2 receptor-bearing Schaffer collateral terminals, a transient 2-fold increase in Y2 receptor affinity was observed after 4-12 hr, with a later slow decline. No change was seen in Y2 mRNA expression in CA2/CA3 pyramidal cells, from which Schaffer collaterals originate. Conversely, in granule cells of the dentate gyrus, markedly elevated Y2 mRNA concentrations were observed (by 740% in the dorsal hippocampus) 24-48 hr after kainate injection. At the same time, a marked and lasting (up to 6 months) increase in the number of Y2 receptor sites (by 800%) was seen in the dentate hilus, which is innervated densely by mossy fibers. The early increase in Y2 receptor affinity in Schaffer collaterals was accompanied by a 60% decrease in the EC50 of peptide YY3-36 in inhibiting K(+)-stimulated glutamate release in hippocampal slices from kainic acid-treated rats. Our data indicate transient up-regulation of presynaptic Y2 receptors in Schaffer collaterals by a change in affinity and a permanent de novo synthesis of presynaptic Y2 receptors in granule cells/mossy fibers. These changes may cause augmented presynaptic inhibition of glutamate release from different hippocampal sites and, in conjunction with increased concentrations of neuropeptide tyrosine in mossy fibers, may represent an endogenous reactive anticonvulsant mechanism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0026-895X
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9443927-Animals, pubmed-meshheading:9443927-Autoradiography, pubmed-meshheading:9443927-Behavior, Animal, pubmed-meshheading:9443927-Binding, Competitive, pubmed-meshheading:9443927-Disease Models, Animal, pubmed-meshheading:9443927-Epilepsy, Temporal Lobe, pubmed-meshheading:9443927-Excitatory Amino Acid Agonists, pubmed-meshheading:9443927-Glutamic Acid, pubmed-meshheading:9443927-In Situ Hybridization, pubmed-meshheading:9443927-Iodine Radioisotopes, pubmed-meshheading:9443927-Kainic Acid, pubmed-meshheading:9443927-Kinetics, pubmed-meshheading:9443927-Male, pubmed-meshheading:9443927-Mossy Fibers, Hippocampal, pubmed-meshheading:9443927-Peptide YY, pubmed-meshheading:9443927-Pyramidal Cells, pubmed-meshheading:9443927-RNA, Messenger, pubmed-meshheading:9443927-Rats, pubmed-meshheading:9443927-Rats, Sprague-Dawley, pubmed-meshheading:9443927-Receptors, Neuropeptide Y, pubmed-meshheading:9443927-Up-Regulation
pubmed:year
1998
pubmed:articleTitle
Up-regulation of neuropeptide Y-Y2 receptors in an animal model of temporal lobe epilepsy.
pubmed:affiliation
Department of Pharmacology, University of Innsbruck, Austria.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't