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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12 Pt 1
|
| pubmed:dateCreated |
1998-2-19
|
| pubmed:abstractText |
To study potential ionic factors predisposing to vascular disease in hypertension, particularly among black subjects, we used a recently developed combined magnesium and calcium specific, ion selective electrode apparatus to measure extracellular ionized calcium (Ca-ion), ionized magnesium (Mg-ion), and Ca-ion/Mg-ion ratios in the serum of fasting, nonmedicated white and black normotensive (n = 61) and hypertensive (n = 23) subjects, studied consecutively in a tertiary referral center. Both race and blood pressure status had independent effects on the distribution of Mg-ion values. Although Mg-ion levels for the group as a whole were lower in hypertensive versus in normotensive subjects (0.571+/-0.012 v 0.601+/-0.005 mmol/L; P < .01), this was only true of white subjects (0.579+/-0.021 v 0.620+/-0.006 mmol/L; P = .0095). The lack of a significant difference in Mg-ion levels between black hypertensive versus normotensive subjects (0.553+/-0.012 v 0.577+/-0.007 mmol/L, P = NS) was attributable to the significantly lower Mg-ion levels present in normotensive blacks compared to those in normotensive white subjects (0.577+/-0.007 v 0.620+/-0.006 mmol/L, P = .0001). Resultant Ca-ion/Mg-ion ratios were elevated in all black subjects and in white hypertensive subjects. These data support the presence among hypertensives and among black subjects (independently of blood pressure) of a consistent depletion of circulating magnesium and of an imbalance of calcium and magnesium that may potentiate vascular disease among these subjects.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0895-7061
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1420-4
|
| pubmed:dateRevised |
2009-2-24
|
| pubmed:meshHeading |
pubmed-meshheading:9443780-African Continental Ancestry Group,
pubmed-meshheading:9443780-Blood Pressure,
pubmed-meshheading:9443780-Calcium,
pubmed-meshheading:9443780-European Continental Ancestry Group,
pubmed-meshheading:9443780-Female,
pubmed-meshheading:9443780-Humans,
pubmed-meshheading:9443780-Hypertension,
pubmed-meshheading:9443780-Magnesium,
pubmed-meshheading:9443780-Male
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Serum ionized magnesium: relation to blood pressure and racial factors.
|
| pubmed:affiliation |
Cardiovascular Center, New York Hospital-Cornell Medical Center, New York, USA.
|
| pubmed:publicationType |
Journal Article
|