rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1998-2-6
|
pubmed:abstractText |
Edatrexate and carboplatin are each active single agents in the treatment of non-small-cell lung cancer (NSCLC). Preclinical studies in NSCLC lines have demonstrated schedule-dependent synergy of edatrexate followed by carboplatin. In a phase I trial, we demonstrated the tolerability of this combination, the ability of ice-chip cryotherapy to ameliorate dose-limiting mucositis, and promising activity in NSCLC. This phase II trial (SWOG 9207) was undertaken to investigate the efficacy of this regimen in stage IV NSCLC.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0344-5704
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
41
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
75-8
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:9443617-Adult,
pubmed-meshheading:9443617-Aged,
pubmed-meshheading:9443617-Aminopterin,
pubmed-meshheading:9443617-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9443617-Carboplatin,
pubmed-meshheading:9443617-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:9443617-Drug Administration Schedule,
pubmed-meshheading:9443617-Female,
pubmed-meshheading:9443617-Humans,
pubmed-meshheading:9443617-Lung Neoplasms,
pubmed-meshheading:9443617-Male,
pubmed-meshheading:9443617-Middle Aged,
pubmed-meshheading:9443617-Mouth Mucosa,
pubmed-meshheading:9443617-Neutropenia,
pubmed-meshheading:9443617-Survival Analysis,
pubmed-meshheading:9443617-Treatment Outcome
|
pubmed:year |
1997
|
pubmed:articleTitle |
Phase II trial of edatrexate plus carboplatin in metastatic non-small-cell lung cancer: a Southwest Oncology Group study.
|
pubmed:affiliation |
University of California at Davis, Sacramento 95817, USA.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Multicenter Study,
Clinical Trial, Phase II
|