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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-2-4
|
| pubmed:abstractText |
Hemizygous germ-line defects in mismatch repair (MMR) genes underlie hereditary nonpolyposis colorectal cancer (HNPCC). Loss of the wild-type allele results in a mutator phenotype, accelerating tumorigenesis. Tumorigenesis specifically occurs in the gastrointestinal and genitourinary tracts; the cause of this tissue specificity is elusive. To understand the etiology and tissue distribution of tumors in HNPCC, we have developed mouse models carrying a deficiency in the MMR gene Msh2. Most of the completely Msh2-deficient mice succumbed to lymphomas at an early age; lymphomagenesis was synergistically enhanced by exposure to ethylnitrosourea. Lymphomas were absent in immunocompromised Tap1-/-;Msh2-/- mice; these mice generally succumbed to HNPCC-like tumors. Together, these data suggest that the HNPCC tumor spectrum is determined by exposure of MMR-deficient cells to exogenous mutagens, rather than by tissue-specific loss of the wild-type MMR allele or by immune surveillance. Msh2 hemizygous mice had an elevated tumor incidence that, surprisingly, was rarely correlated with loss of the Msh2+ allele. To develop a model for intestinal tumorigenesis in HNPCC, we introduced the Min allele of the Apc tumor suppressor gene. We observed loss of the wild-type Msh2 allele in a significant fraction of intestinal tumors in Apc+/Min;Msh2+/- mice. In some of the latter tumors, one area of the tumor displayed loss of the Msh2+ allele, but not of the Apc+ allele, whereas another area displayed the inverse genotype. This apparent biclonality might indicate a requirement for collaboration between independent tumor clones during intestinal tumorigenesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenomatous Polyposis Coli Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ethylnitrosourea,
http://linkedlifedata.com/resource/pubmed/chemical/Msh2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
58
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
248-55
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9443401-Adenomatous Polyposis Coli Protein,
pubmed-meshheading:9443401-Animals,
pubmed-meshheading:9443401-Clone Cells,
pubmed-meshheading:9443401-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:9443401-Cytoskeletal Proteins,
pubmed-meshheading:9443401-DNA-Binding Proteins,
pubmed-meshheading:9443401-Disease Models, Animal,
pubmed-meshheading:9443401-Ethylnitrosourea,
pubmed-meshheading:9443401-Female,
pubmed-meshheading:9443401-Gene Deletion,
pubmed-meshheading:9443401-Immunocompromised Host,
pubmed-meshheading:9443401-Loss of Heterozygosity,
pubmed-meshheading:9443401-Lymphoma,
pubmed-meshheading:9443401-Male,
pubmed-meshheading:9443401-Mice,
pubmed-meshheading:9443401-Mice, Inbred BALB C,
pubmed-meshheading:9443401-Mice, Inbred C57BL,
pubmed-meshheading:9443401-Mice, Knockout,
pubmed-meshheading:9443401-Mice, Mutant Strains,
pubmed-meshheading:9443401-MutS Homolog 2 Protein,
pubmed-meshheading:9443401-Proto-Oncogene Proteins,
pubmed-meshheading:9443401-Survival Rate
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Mouse models for hereditary nonpolyposis colorectal cancer.
|
| pubmed:affiliation |
Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|