| pubmed-article:9442377 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9442377 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9442377 | lifeskim:mentions | umls-concept:C0086282 | lld:lifeskim |
| pubmed-article:9442377 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:9442377 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:9442377 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:9442377 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:9442377 | lifeskim:mentions | umls-concept:C1705630 | lld:lifeskim |
| pubmed-article:9442377 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:9442377 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:9442377 | pubmed:dateCreated | 1998-3-26 | lld:pubmed |
| pubmed-article:9442377 | pubmed:abstractText | A kappa B-site was identified in the promoter of the intercellular adhesion molecule-1 (ICAM-1) gene, which is involved in regulation of ICAM-1 expression by tumor necrosis factor alpha (TNF-alpha) and glucocorticoids. We now report on the transcription factors which bind and transactivate this enhancer sequence. In vitro, the ICAM-1 kappa B site appeared to bind RelA and c-Rel homodimers as well as heterodimers with NF-kappa B1, but weakly NF-kappa B1 homodimers. In addition, both RelA and c-Rel, but not NF-kappa B1, were shown to transactivate an ICAM-1 kappa B-reporter construct. In monocytic THP-1 cells TNF-alpha induced two nuclear complexes which in vitro bound to the ICAM-1 kappa B site. Using antibodies in an electrophoretic mobility supershift assay, one of these complexes was shown to contain NF-kappa B1 and RelA, and to bind with higher affinity to the consensus kappa B site in the HIV long terminal repeat. The second complex contained RelA, and exhibited higher affinity towards the ICAM-1 kappa B than to the HIV kappa B site. The glucocorticoid receptor was shown to repress activity of both the RelA homodimer and the NF-kappa B1/RelA heterodimer. We argue that in vivo RelA homodimers are likely to play a dominant role in TNF-alpha-induced ICAM-1 transcription in monocytic cells. | lld:pubmed |
| pubmed-article:9442377 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9442377 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9442377 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9442377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9442377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9442377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9442377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9442377 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9442377 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9442377 | pubmed:issn | 0171-2985 | lld:pubmed |
| pubmed-article:9442377 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:9442377 | pubmed:author | pubmed-author:WissingWW | lld:pubmed |
| pubmed-article:9442377 | pubmed:author | pubmed-author:KoendermanLL | lld:pubmed |
| pubmed-article:9442377 | pubmed:author | pubmed-author:van de... | lld:pubmed |
| pubmed-article:9442377 | pubmed:author | pubmed-author:CaldenhovenEE | lld:pubmed |
| pubmed-article:9442377 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9442377 | pubmed:volume | 198 | lld:pubmed |
| pubmed-article:9442377 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9442377 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9442377 | pubmed:pagination | 50-64 | lld:pubmed |
| pubmed-article:9442377 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9442377 | pubmed:meshHeading | pubmed-meshheading:9442377-... | lld:pubmed |
| pubmed-article:9442377 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9442377 | pubmed:articleTitle | NF-kappa B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells. | lld:pubmed |
| pubmed-article:9442377 | pubmed:affiliation | Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Nijmegen, The Netherlands. | lld:pubmed |
| pubmed-article:9442377 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9442377 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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