Linked Life Data

944172

Source:http://linkedlifedata.com/resource/pubmed/id/944172

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1976-7-6
pubmed:abstractText
The effect on pilocarpine flux across rabbit cornea in vitro by a noncross-linked polymeric gel vehicle was measured. A closed system transport chamber was used. Its design featured continuous flow of a tear analog but excluded variables of the internal eye. Results were compared to previously determined data in the same chamber system for cross-linked hydrogel buttons and for free pilocarpine fluid. Gel-mediated flux was equal to that with lens buttons to 90 minutes in the case of a 30 per cent gel (viscosity approximately 70,000 centipoises). Elution by the tear analog system limited flux duration of gels relative to lenses. Greater viscosity of 30 per cent gel relative to 25 per cent gel (approximately 15,000 centipoises) was associated with prolonged transcorneal drug flux. The congruence of flux slopes for 30 per cent gel and lens button vehicles despite the difference in available dose suggests saturable mediation of pilocarpine transport across the cornea, but a greater "flux efficiency" through 90 minutes for 30 per cent gel.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0020-9988
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
324-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Quantitation of pilocarpine delivery across isolated rabbit cornea by noncross-linked high viscosity polymer gel.
pubmed:publicationType
Journal Article